5018-23-5

Basic information

• Product Name: 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE
• Synonyms: 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE;4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESNLFONAMIDE;6-Chloro-5-methoxy-4-(sulfanilamido)pyrimidine;4-Amino-N-(6-chloro-5-methoxypyrimidin-4-yl)benzenesulfonamide;4-Sulfanilamide-5-Methoxyl-6-Chloro Pyrimidine
• CAS NO: 5018-23-5
• Molecular Formula: C₁₁H₁₁ClN₄O₃S
• Molecular Weight: 314.74804
• Mol File: 5018-23-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200-202 °C(Solv: water (7732-18-5); ethanol (64-17-5))
• Boiling Point: 531.3±60.0 °C(Predicted)
• Appearance: /
• Density: 1.548±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: -0.38±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE(5018-23-5)
• EPA Substance Registry System: 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE(5018-23-5)

Safety Data

• Hazardous Substances Data: 5018-23-5(Hazardous Substances Data)

Usage

Description

4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE is a chemical compound that is identified as an impurity in the synthesis of Sulfadoxine (S699070), which is an antibacterial agent. 4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE has a specific molecular structure that differentiates it from other related compounds and is characterized by its chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
4-AMINO-N-(6-CHLORO-5-METHOXY-4-PYRIMIDINYL)BENZENESULFONAMIDE is used as an impurity in the synthesis of Sulfadoxine (S699070) for its antibacterial properties. The presence of this compound in the synthesis process may affect the overall efficacy and quality of the final product, making it an important consideration in the development and production of Sulfadoxine.
In the context of pharmaceuticals, the compound's role as an impurity highlights the need for careful monitoring and control of the synthesis process to ensure the safety and effectiveness of the resulting antibacterial drug. This may involve the development of purification techniques or alternative synthesis methods to minimize the presence of this compound in the final product.

Upstream product

• 63-74-1 sulfanilamide 
• 5018-38-2 4,6-dichloro-5-methoxypyrimidine 
• 127-56-0 sodium 4-aminobenzenesulfonylacetamide 
• 10103-15-8 sodium salt of sulfanilamide 

Downstream Products

• 2447-57-6 sufadoxine 

Relevant articles and documents

Stable isotope labeled sulfadoxine and synthesis method thereof

The invention discloses stable isotope labeled sulfadoxine and a synthesis method thereof. The synthesis method comprises following steps: S1, sulfanilamide and sodium hydroxide are subjected to a reaction, and sulfanilamide sodium salt is prepared; S2, s

4 - (P-amino sulfonaide yl) - 5-methoxy -6 chloro pyrimidine preparation method

The invention relates to a preparation method of 4-(p-anilinesulfonamide)-5-methoxy-6 chloropyrimidine. The preparation method comprises following steps: (a) 1-butyl-3-methylimidazolium chloride and sulfanilamide sodium are delivered into a reaction container, 5-methoxy-4,6-dichloropyrimidine is added after stirring, and reaction is carried out at a temperature of 88 to 92 DEG C for 0.5 to 2h so as to obtain a mixture; (b) dilute hydrochloric acid is added into the mixture so as to adjust pH value to 7.0 to 7.2, the mixture is cooled to 15 to 20 DEG C for crystallization, and a mother liquor and a filter residue are obtained via centrifugation; and (c) the mother liquor is heated to 68 to 72 DEG C, dilute hydrochloric acid is added to adjust pH value to 3.8 to 4.1, discharging is performed when an obtained mixed material is still hot, and finished products are obtained via centrifuge dewatering. According to the preparation method of 4-(p-anilinesulfonamide)-5-methoxy-6 chloropyrimidine, 1-butyl-3-methylimidazolium chloride is taken as a solvent to replace DMF which is high in boiling point, and distillation recovery of DMF is not needed, so that on the one hand, demands on production equipment are wakened, and on the other hand, energy consumption of enterprises is reduced greatly, and demands of the state on energy saving and environmental protection are satisfied.