5021-45-4Relevant articles and documents
A facile synthesis of quinoxalines by using SO42?/ZrO2-TiO2 as an efficient and recyclable heterogeneous catalyst
Deshmukh, Tejshri R.,Dhumal, Sambhaji T.,Karale, Akshay Y.,Patil, Meghshyam K.,Shelke, Sushil V.
supporting information, (2022/03/02)
Quinoxaline derivatives have been synthesized in good to excellent yields by the cyclocondensation reaction of o-pheneylenediamine with substituted phenacyl bromides/benzil in the presence of SO42?/ZrO2-TiO2 as an efficient and heterogeneous catalyst. The catalyst can be recovered up to five catalytic cycles without significant loss in catalytic activity. The reported SO42?/ZrO2-TiO2 catalyst has been thoroughly characterized by using infrared spectroscopy, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and powder X-ray diffraction (XRD). Here, we have used ethanol as a green solvent in this cyclocondensation. This new method has several advantages, such as excellent yields, short reaction time, nontoxic, and easily recoverable catalyst.
Method for synthesizing 2-aryl quinoxaline and 3-aryl quinoxaline-2(1H)-one based on mechanical grinding of aryl diazonium salt
-
Paragraph 0128-0133, (2022/04/06)
The invention discloses a method for synthesizing 2-aryl quinoxaline and 3-aryl quinoxaline-2 (1H)-one based on mechanical grinding of aryl diazonium salt. According to the method, an active free radical precursor is generated through mechanical induction, 2-aryl quinoxaline and 3-aryl quinoxaline-2 (1H)-one are synthesized under the condition of mechanical grinding, and 2-aryl quinoxaline and 3-aryl quinoxaline-2 (1H)-one are prepared from aryl diazonium salt through a single electron transfer process without a solvent or even a catalyst in the reaction. The method is simple in synthesis step and green, does not need to consume the solvent, can be used for large-scale production, and provides a new and green synthesis strategy for synthesizing quinoxaline compounds.
Synthesis of polycyclic 3,3′-spirooxindoles and some new 2-arylquinoxalines from (E/Z)- 1-(2-oxo-2-arylethylidene)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones
Amanollahi, Ruhollah,Baradarani, Mehdi M.,Fazlelahi, Hadi Zare,Joule, John A.,Saatluo, Bahman Ebrahimi
, (2022/01/26)
A facile protocol to access a novel series of spirocyclodiazepines from cyclocondensation of 1-(2-oxo-2-arylethylidene)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-ones (derived from 5,6-dihydro-1H-pyrrolo[3,2,1-ij]quinolone-1,2(4H)?dione) with ethane-1,2-diamines and benzene-1,2-diamines, generates polycyclic spirooxindoles and unexpectedly produces 2-arylquinoxalines instead of spiro[indole-1,5-benzodiazepines], respectively, in the presence of p-TSA as an efficient catalyst in a green solvent.
