5028-32-0Relevant articles and documents
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors
Frohn, Mike,Viswanadhan, Vellarkad,Pickrell, Alexander J.,Golden, Jennifer E.,Muller, Kristine M.,Buerli, Roland W.,Biddlecome, Gloria,Yoder, Sean C.,Rogers, Norma,Dao, Jennifer H.,Hungate, Randall,Allen, Jennifer R.
scheme or table, p. 5023 - 5026 (2009/05/26)
We report the structure-based design and synthesis of a novel series of aza-benzimidazoles as PHD2 inhibitors. These efforts resulted in compound 22, which displayed highly potent inhibition of PHD2 function in vitro.
MIGRATION OF THE N-SUBSTITUENT IN THE SERIES OF IMIDAZO- AND IMIDAZOPYRIDINE DERIVATIVES
Yutilov, Yu. M.,Mikhailova, L. E.,Ignatenko, A. G.
, p. 394 - 395 (2007/10/02)
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