50288-62-5

Basic information

• Product Name: (D,L)-threo-α-Phenyl-
• Synonyms: (D,L)-threo-α-Phenyl-;(D,L)-threo-α-Phenyl-2-piperidineacetaMide;Threo phenyl-2-piperidyl acetamide
• CAS NO: 50288-62-5
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.29482
• Product Categories: Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 50288-62-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 174-176 °C
• Boiling Point: 406.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.097±0.06 g/cm3(Predicted)
• PKA: 16.16±0.50(Predicted)
• CAS DataBase Reference: (D,L)-threo-α-Phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: (D,L)-threo-α-Phenyl-(50288-62-5)
• EPA Substance Registry System: (D,L)-threo-α-Phenyl-(50288-62-5)

Safety Data

• Hazardous Substances Data: 50288-62-5(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Upstream product

• 19395-39-2 dl-erythro-α-phenyl-α-(2-piperidyl)acetamide 
• 19395-39-2 (-) (R or S)-phenyl-[(S or R)-[2]piperidyl]-acetic acid amide 
• 7251-52-7 2-phenyl-2-(pyridin-2-yl)acetamide 
• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 109-09-1 2-chloropyridine 
• 140-29-4 phenylacetonitrile 
• 1252975-08-8 2-phenyl-2-piperidin-2-ylidene-acetamide 

Downstream Products

• 19395-39-2 (-) (R or S)-phenyl-[(S or R)-[2]piperidyl]-acetic acid amide 
• 19395-39-2 (+) (R or S)-phenyl-[(R or S)-[2]piperidyl]-acetic acid amide 
• 160707-39-1 d-erythro-α-piperid-2-ylphenylacetamide 
• 1076192-92-1 ritalinic acid 

Relevant articles and documents

An Improved and Efficient Process for the Production of Highly Pure Dexmethylphenidate Hydrochloride

The present work describes an efficient and commercially viable process for the synthesis of dexmethylphenidate hydrochloride (1), a mild nervous system stimulant. The overall yield is 23% with ~99.9% purity (including seven chemical steps). Formation and control of possible impurities are also described in this report.

A PROCESS FOR THE PREPARATION OF ALPHA-ARYL-ALPHA-PIPERID-2-YL-ACETAMIDES AND THE ACID HYDROLYSIS THEREOF

A process for the preparation of -aryl--piperid-2-yl-acetamides of formula (I) in which Ar is as defined in the disclosure, by catalytic reduction of α-aryl-α-pyridin-2-yl-acetamides (II) with rhodium catalysts. Acetamides of formula (II) can subsequently by hydrolysed to the corresponding arylacetic acids, e. g. ritalinic acid, a direct precursor of methylphenidate.