50293-91-9

Basic information

• Product Name: (S)-Albuterol Hydrochloride
• Synonyms: (S)-Albuterol Hydrochloride;(S)-SalbutaMol Hydrochloride;(α1S)-α1-[[(1,1-DiMethylethyl)aMino]Methyl]-4-hydroxy-1,3-benzenediMethanol Hydrochloride;(+)-Salbutamol hydrochlorid;(S)- Salbutamol ((S)-Albuterol);(S)-4-(2-(tert-butylamino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol hydrochloride
• CAS NO: 50293-91-9
• Molecular Formula: C13H22ClNO3
• Molecular Weight: 275.77168
• Product Categories: Amines;Aromatics;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 50293-91-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, Under inert atmosphere
• Solubility: Methanol (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: (S)-Albuterol Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Albuterol Hydrochloride(50293-91-9)
• EPA Substance Registry System: (S)-Albuterol Hydrochloride(50293-91-9)

Safety Data

• Hazardous Substances Data: 50293-91-9(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Upstream product

• 54208-72-9 2-(tert-butylamino)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanol 
• 39235-58-0 4-hydroxy-3-hydroxymethylacetophenone 
• 54030-34-1 1-(2,2-dimethyl-4H-benzo[d][1,3]dioxan-6-yl)ethanone 
• 34391-04-3 Levalbuterol 
• 174607-68-2 (R)-1-[4-benzyloxy-3-hydroxymethylphenyl]-2-tert-butylaminoethanol 
• 238762-31-7 (R)-2-(N-tert-butylamino)-1-(2,2-dimethyl-4H-benzo[3,4-e]1,3-dioxin-6-yl)ethanol 
• 90-02-8 salicylaldehyde 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 

Relevant articles and documents

Salbutamol hydrochloride preparation method suitable for industrial production

The invention discloses a salbutamol hydrochloride preparation method suitable for industrial production. 4-hydroxy-3-hydroxymethylacetophenone used as an initial raw material undergoes epoxy protection, oxidation, reductive amination and deprotection salification to obtain salbutamol hydrochloride. The method has the advantages of no bromination process in the whole reaction process, avoidance ofuse of high-risk reagents, small environmental pollution, low device requirements, simplicity in operation, mild reaction conditions, simplified steps, low production cost, and suitability for industrial production.

(R)- albuterol hydrochloride asymmetric preparation method (by machine translation)

The present invention relates to a high-efficient chiral catalyst synthesis of (R)- albuterol hydrochloride the asymmetric synthesis of the new method, the synthesis step includes: 1) salicylaldehyde with a halo of acetyl halogen crafts acylation reaction halo; 2) obtained after the the halogenated ketone uses unclebutylamine amine solution obtained after hydrolysis to the protection of the salicylaldehyde aminoketone; 3) this aminoketone in chiral amino alcohol derivative of the chiral borane the presence of a catalyst, is reduced to (R)- albuterol crude product, then the purified hydrochloric salt to obtain the high purity of the (R)- albuterol hydrochloride. (by machine translation)

PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

A process for the preparation of optically pure R (?) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 /sub