503160-54-1

Basic information

• Product Name: Furo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(1,1-dimethylethyl)amino]-1,3-dimethyl-5-(4-nitrophenyl)-
• Synonyms: Furo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(1,1-dimethylethyl)amino]-1,3-dimethyl-5-(4-nitrophenyl)-
• CAS NO: 503160-54-1
• Molecular Formula: C18H20N4O5
• Molecular Weight: 372.38
• Mol File: 503160-54-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Furo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(1,1-dimethylethyl)amino]-1,3-dimethyl-5-(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Furo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(1,1-dimethylethyl)amino]-1,3-dimethyl-5-(4-nitrophenyl)-(503160-54-1)
• EPA Substance Registry System: Furo[2,3-d]pyrimidine-2,4(1H,3H)-dione, 6-[(1,1-dimethylethyl)amino]-1,3-dimethyl-5-(4-nitrophenyl)-(503160-54-1)

Safety Data

• Hazardous Substances Data: 503160-54-1(Hazardous Substances Data)

Upstream product

• 769-42-6 1,3-dimethylbarbituric acid 
• 119072-55-8 tert-butylisonitrile 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

One-pot three component condensation reaction in water: An efficient and improved procedure for the synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones

The environment-friendly three component condensation reactions of N,N′-dimethylbarbituric acid, 4-nitrobenzaldehyde and alkyl or aryl isocyanides to afford the corresponding furo[2,3-d]pyrimidine-2,4(1H,3H)-diones, in water, in high yields aft

A simple and convenient approach to the synthesis of aminofuropyrimidindiones

The one-pot three-component reactions of 1,3-dimethylbarbituric acid, aromatic aldehydes and alkyl or aryl isocyanides proceed smoothly at room temperature to give the corresponding 5-aryl-6-alkyl or arylamino-1,3- dimethylfuro [2,3-d] pyrimidine-2, 4 (1H,3H)-dione derivatives in good to excellent yields within 30 minutes in DMF. This three-component reaction represents a facile and efficient route to the described biologically interesting molecules.