5033-28-3

Basic information

• Product Name: 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE
• Synonyms: BUTTPARK 52\12-19;ART-CHEM-BB B022963;AKOS B022963;4-CHLOROBENZAMIDE OXIME;4-CHLORO-N-HYDROXY-BENZAMIDINE;4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE;4-CHLORO-N-HYDROXYBENZENECARBOXIMIDAMIDE;(Z)-4-chloro-N'-hydroxybenzamidine
• CAS NO: 5033-28-3
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.6
• Product Categories: Aromatic Hydrazides, Hydrazines, Hydrazones and Oximes;pharmacetical
• Mol File: 5033-28-3.mol
• Article Data: 125

Chemical Properties

• Melting Point: 131 °C
• Boiling Point: 334.619 °C at 760 mmHg
• Flash Point: 156.172 °C
• Appearance: /
• Density: 1.368 g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(5033-28-3)
• EPA Substance Registry System: 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(5033-28-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5033-28-3(Hazardous Substances Data)

Usage

Description

4-Chloro-N'-hydroxybenzenecarboximidamide, also known as 4-chlorobenzamidoxime, is an organic compound with the molecular formula C7H6ClN2O2. It is a derivative of benzenecarboximidamide, featuring a chlorine atom at the 4-position and a hydroxyl group attached to the nitrogen atom. 4-CHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE is known for its potential applications in various industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
4-Chloro-N'-hydroxybenzenecarboximidamide is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Chemical Synthesis:
In the field of organic chemistry, 4-chloro-N'-hydroxybenzenecarboximidamide serves as a versatile building block for the synthesis of a wide range of chemical compounds. Its reactivity and functional groups make it a valuable precursor for creating complex molecules with diverse applications.
Used in Research and Development:
Due to its unique chemical structure, 4-chloro-N'-hydroxybenzenecarboximidamide is utilized in research and development for studying various chemical reactions and exploring new synthetic pathways. It can be used to investigate the properties of related compounds and to develop new methodologies in organic synthesis.
Specific Application:
4-Chloro-N'-hydroxybenzenecarboximidamide is used to synthesize O-(3-piperidino-2-hydroxy-1-propyl)-4-chloro-benzamidoxime dihydrochloride, which is a compound with potential applications in various fields, such as pharmaceuticals or chemical research. The synthesis of this compound demonstrates the utility of 4-chloro-N'-hydroxybenzenecarboximidamide as a starting material for the development of new and innovative products.

Upstream product

• 68451-72-9 (Z)-O-Benzoyl-4-chlorbenzamidoxim 
• 124-41-4 sodium methylate 
• 623-03-0 4-Cyanochlorobenzene 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 67-56-1 methanol 
• 125338-28-5 3-(4-Chloro-phenyl)-5-{(E)-2-[3-(4-chloro-phenyl)-isoxazol-4-yl]-vinyl}-4,5-dihydro-[1,2,4]oxadiazole 
• 68451-91-2 C₁₄H₁₀ClN₃O₄ 
• 68451-85-4 C₁₄H₁₀Cl₂N₂O₂ 
• 104-88-1 4-chlorobenzaldehyde 
• 3848-36-0 4-chlorobenzaldoxime 
• 637-87-6 1-Chloro-4-iodobenzene 
• 140-53-4 p-chlorobenzyl cyanide 
• 15500-74-0 4-chlorobenzonitrile N-oxide 
• 766-84-7 3-chloro-benzonitrile 

Downstream Products

• 69793-02-8 3-(4-chloro-phenyl)-5-(1-ethyl-propyl)-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 32212-16-1 4-(4-chloro-phenyl)-2-(2,4,6-trimethyl-phenyl)-2,3-dihydro-[1,3,5,2]oxadiazaborole 
• 32212-14-9 4-(4-chloro-phenyl)-2-p-tolyl-2,3-dihydro-[1,3,5,2]oxadiazaborole 
• 32212-17-2 4-(4-chloro-phenyl)-2-naphthalen-1-yl-2,3-dihydro-[1,3,5,2]oxadiazaborole 
• 32212-21-8 4-(4-chloro-phenyl)-3H-[1,3,5,2]oxadiazaborol-2-ol 
• 16013-25-5 5-benzyl-3-(4-chloro-phenyl)-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 16013-22-2 3-(4-chloro-phenyl)-5-methyl-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 10550-15-9 3-(4-chlorophenyl)-1,2,4-oxadiazole 
• 69792-85-4 5-(4-chlorophenyl)-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole 
• 93030-74-1 4-chloro-N-(3-chloro-propionyloxy)-benzamidine 
• 16013-21-1 p-chlorophenyl-5,5-pentamethylene-Δ²-1,2,4-oxadiazoline 
• 86339-12-0 C₁₅H₁₃ClN₂O₂ 
• 75886-55-4 (E)-2-[(4-Chloro-benzimidoyl)-aminooxy]-but-2-enedioic acid dimethyl ester 
• 623-03-0 4-Cyanochlorobenzene 

Relevant articles and documents

Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity

Recent studies have shown that combining kinase inhibitors has additive and synergistic effects. BRAFV600E and p38α have been extensively studied as potential therapeutic targets for a variety of diseases. In keeping with our interest in developing multi-targeted anticancer agents, a series of novel triaryl-imidazole-based analogues containing 3-aryl-1,2,4-oxadiazoles moiety (4a-h, Scaffold B) and their reaction intermediates aryl carboximidamides moiety (3a-h, Scaffold A) have been rationally designed, synthesized, and evaluated in vitro for their antiproliferative activity as dual p38α/BRAFV600E inhibitors. The results revealed that the presence of the carboximidamide moiety is required for activity, and the best activity correlates with the Ar = 1,2-benzodioxole (3e) ≥ 4-CH3O-C6H5-(3c) > 2-naphthyl (3h) > 4-Cl-C6H5 (3b). Ring closure of carboximidamide to 1,2,4-oxadiazole significantly reduces the activity. The results of docking study into p38α revealed higher binding affinities for compounds 3c, 3e, and 3h compared to the co-crystallized ligand, SB2. However, the docking study of compounds 3c and 3e into BRAFV600E revealed slightly lower affinities than vemurafenib.

Synthesis, spectroscopic characterization and DNA/HSA binding studies of (phenyl/naphthyl)ethenyl-substituted 1,3,4-oxadiazolyl-1,2,4-oxadiazoles

Two new series of conjugated arylethenyl-1,3,4-oxadiazolyl-1,2,4-oxadiazoles were obtained and spectroscopically characterized in terms of UV-Vis absorption, fluorescence and interaction with CT-DNA and Human Serum Albumin (HSA) biomolecules. Phenyl- and 1-naphthyl-bearing examples were analysed, and the spectroscopic properties of its substitution series were compared, showing extensive conjugation in all compounds and absorption differences due to both the aryl-ethenyl subunit and substituted phenyl/phenylene at the 1,2,4-oxadiazole side. Strong binding interactions of the obtained compounds with CT-DNA and moderate HSA-association capability were observed spectroscopically, and further docking studies were performed. This journal is

INHIBITOR COMPOUNDS

The disclosure relates to heterocyclic compounds and methods for their preparation. The disclosure provides compounds that may have beneficial therapeutic activity in the treatment of a disease or condition mediated by excessive or otherwise undesirable Des1 and/or fibrotic activity.