5033-95-4

Basic information

• Product Name: 2-Propenoic acid, 3-phenyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2E)-
• CAS NO: 5033-95-4
• Molecular Formula: C19H26O2
• Molecular Weight: 286.414
• Mol File: 5033-95-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3-phenyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3-phenyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2E)-(5033-95-4)
• EPA Substance Registry System: 2-Propenoic acid, 3-phenyl-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2E)-(5033-95-4)

Safety Data

• Hazardous Substances Data: 5033-95-4(Hazardous Substances Data)

Upstream product

• 89-78-1 menthol 
• 140-10-3 (E)-3-phenylacrylic acid 
• 102-92-1 Cinnamoyl chloride 
• 2216-51-5 (-)-menthol 
• 102-92-1 cinnamoyl chloride 
• 141-82-2 malonic acid 
• 100-52-7 benzaldehyde 

Downstream Products

• 109761-20-8 4,5-diphenyl-2-pyrrolidone 
• 126491-58-5 β,γ-diphenyl-γ-aminobutyric acid hydrochloride 
• 73249-94-2 menthyl 5-oxo-3,5-diphenylpentanoate 
• 111832-32-7 (2S,3R)-3-Phenyl-oxirane-2-carboxylic acid (1S,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester 
• 73249-92-0 phenyl-3 cyclohexyl-3 (oxo-2') propanoate de menthyle 
• 114466-83-0 (2S,3S)-(-)-menthyl 2-amino-3-((4-methoxybenzyl)thio)-3-phenylpropionate 
• 50707-55-6 cis-(2S,3S)-2-((-)-menthyloxycarbonyl)-3-phenylaziridine 
• 114529-83-8 trans-(2R,3S)-2-((-)-menthyloxycarbonyl)-3-phenylaziridine 
• 114529-82-7 trans-(2S,3R)-2-((-)-menthyloxycarbonyl)-3-phenylaziridine 
• 50896-31-6 cis-(2R,3R)-2-((-)-menthyloxycarbonyl)-3-phenylaziridine 
• 50707-54-5 (Z)-(-)-menthyl 2-bromocinnamate 
• 114466-82-9 (E)-(-)-menthyl 2-bromocinnamate 

Relevant articles and documents

Conjugate addition of aryl nucleophiles to α,β-unsaturated cinnamic acid derivatives containing Evans type chiral auxiliaries

Cinnamides containing oxazolidin-2-one type auxiliaries have been prepared. A novel pathway to chiral 4-aryl-6-methyl-3,4-dihydrocoumrines via the asymmetric conjugate addition of arylmagnesium bromides to these cinnamides is described.

Modified Yamaguchi reagent: Convenient and efficient esterification

A convenient and efficient esterification method that used a modified Yamaguchi reagent (2,4,6-trichlorobenzoyl chloride-4-dimethylaminopyridine) and avoided use not only of intractable acid chloride but also of acid anhydrides was proposed. The reaction mechanism was described by Fourier transform infrared spectroscopy and supported by a density functional theory calculation.

Highly diastereoselective synthesis of vinylcyclopropane derivatives with (-)-8-phenylmenthol as chiral auxiliary

The silylated telluronium allylide 4, generated in situ from the corresponding telluronium salt in the presence of LiTMP, reacted with (-)-8-phenylmenthyl α,β-unsaturated esters to afford trans-2-silylvinyl-trans-3-substituted cyclopropyl esters with high diastereoselectivity in high yields. The absolute configuration was determined by chemical transformation. A mechanistic rationale is proposed.