5034-20-8

Basic information

• Product Name: 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one
• Synonyms: 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one
• CAS NO: 5034-20-8
• Molecular Weight: 156.225
• Mol File: 5034-20-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one(5034-20-8)
• EPA Substance Registry System: 1-(4-hydroxy-4-methylcyclohexyl)ethan-1-one(5034-20-8)

Safety Data

• Hazardous Substances Data: 5034-20-8(Hazardous Substances Data)

Upstream product

• 6090-09-1 (+-)-4-acetyl-1-methylcyclohexene 
• 85734-09-4 p-menthane-1,8,9-triol 
• 138-87-4 beta-terpineol 
• 2451-01-6 cis-4-hydroxy-α,α,4-trimethyl-cyclohexanemethanol, monohydrate 
• 90113-41-0 4-hydroxy-4-methylcyclohexane-1-carboxylic acid 

Relevant articles and documents

Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors

Inhibition of transforming growth factor β (TGF-β) type 1 receptor (ALK5) provides a feasible approach for the treatment of fibrotic diseases and malignant tumors. In this study, we designed and synthesized a new series of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives, and evaluated biologically as TGF-β type 1 receptor inhibitors. The most potent compound 15r inhibited the ALK5 enzyme and NIH3T3 cell viability with IC50 values of 44 and 42.5 nM, respectively. Compound 15r also displayed better oral plasma exposure and excellent bioavailability than LY-3200882, and in vivo inhibited 65.7% of the tumor growth in a CT26 xenograft mouse model.