50353-99-6

Basic information

• Product Name: Ethanone, 2-(4-methylphenyl)-1,2-diphenyl-
• CAS NO: 50353-99-6
• Molecular Formula: C21H18O
• Molecular Weight: 286.373
• Mol File: 50353-99-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-(4-methylphenyl)-1,2-diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-(4-methylphenyl)-1,2-diphenyl-(50353-99-6)
• EPA Substance Registry System: Ethanone, 2-(4-methylphenyl)-1,2-diphenyl-(50353-99-6)

Safety Data

• Hazardous Substances Data: 50353-99-6(Hazardous Substances Data)

Upstream product

• 1882-56-0 2-(4-methylphenyl)-2-phenylacetic acid 
• 119-53-9 2-hydroxy-2-phenylacetophenone 
• 110247-85-3 (1RS,2RS)-1,2-diphenyl-1-p-tolyl-ethane-1,2-diol 
• 134-81-6 benzil 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 134-84-9 4-Methylbenzophenone 
• 100-47-0 benzonitrile 
• 451-40-1 phenyl benzyl ketone 
• 99-99-0 1-methyl-4-nitrobenzene 
• 52056-24-3 2-Hydroxy-1,2-diphenyl-2-(p-tolyl)ethanone 
• 624-31-7 4-tolyl iodide 
• 108-88-3 toluene 
• 611-71-2 MANDELIC ACID 
• 98-86-2 acetophenone 

Downstream Products

• 532-32-1 sodium benzoate 
• 134-84-9 4-Methylbenzophenone 
• 620-83-7 1-methyl-4-(phenylmethyl)benzene 
• 65-85-0 benzoic acid 
• 57272-40-9 2-Hydroperoxy-1,2-diphenyl-2-p-tolyl-ethanone 

Relevant articles and documents

Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes

The palladium-catalyzed α-arylation of ketones with readily available nitroarenes and nitroheteroarenes provides access to useful α-aryl and α-heteroaryl ketones. The use of the Pd/ BrettPhos catalysts was critical to achieve high efficiency for these transformations, whereas other catalysts led to decreased yields or no conversions. The intramolecular type substrate was also applied in this methodology and gave a chromone derivative. Polyaromatic carbonyl compounds can be easily obtained by multicomponent tandem reactions, via nucleophilic aromatic substitution (SNAr) or cross-coupling reaction followed by this denitrative arylation. Kinetic experiments show that the electronic effect of nitrobenzenes has a greater effect on the reaction rate than the electronic effect of ketones.

Metal Free, Direct and Selective Deoxygenation of α-Hydroxy Carbonyl Compounds: Access to α,α-Diaryl Carbonyl Compounds

An efficient, metal free, direct and selective deoxygenation of α-hydroxy carbonyl compounds is achieved with the aid of catalytic amount of aqueous HClO4 (70 %) and triethylsilane as hydride source. A variety of α-hydroxy-α,α-diaryl carbonyl compounds are selectively deoxygenated to give α,α-diaryl carbonyl compounds in good to excellent yields. Intermediacy of α-keto carbenium ion is proposed on the basis of some control experiments and atmospheric pressure chemical ionization mass spectral analysis.

PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.