503536-73-0

Basic information

• Product Name: 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE
• Synonyms: AKOS BAR-0872;5-(4-FLUOROPHENYL)-2-PYRIDINAMINE;2-Amino-5-(4-fluorophenyl)pyridine;5-(4-Fluorophenyl)pyridin-2-aMine
• CAS NO: 503536-73-0
• Molecular Formula: C₁₁H₉FN₂
• Molecular Weight: 188.2
• Mol File: 503536-73-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 320.611°C at 760 mmHg
• Flash Point: 147.7°C
• Appearance: /
• Density: 1.218
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• PKA: 6.19±0.26(Predicted)
• CAS DataBase Reference: 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE(503536-73-0)
• EPA Substance Registry System: 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE(503536-73-0)

Safety Data

• Hazardous Substances Data: 503536-73-0(Hazardous Substances Data)

Usage

General Description

5-(4-FLUOROPHENYL)-2-PYRIDINAMINE, also known as 4-Fluorophenyl-2-aminopyridine, is an organic chemical compound with the molecular formula C11H9FN2. It is a pyridine derivative with a fluorophenyl group attached to the nitrogen atom. 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE is used in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active compounds. It has been studied for its potential as an anti-cancer agent and has also been used as a precursor in the synthesis of novel drug candidates. The chemical structure and properties of 5-(4-FLUOROPHENYL)-2-PYRIDINAMINE make it a valuable tool in medicinal chemistry and drug discovery research.

InChI:InChI=1/C11H9FN2/c12-10-4-1-8(2-5-10)9-3-6-11(13)14-7-9/h1-7H,(H2,13,14)

Upstream product

• 20511-12-0 2-amino-5-iodopyridine 
• 1765-93-1 4-fluoroboronic acid 
• 504-29-0 2-aminopyridine 
• 1072-98-6 5-chloro-2-pyridylamine 
• 71-36-3 butan-1-ol 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 779203-65-5 ethyl-[5-(4-fluoro-phenyl)-pyridin-2-yl]-amine 
• 924279-80-1 2-amino-3-bromo-5-(4-fluorophenyl)pyridine 

Relevant articles and documents

Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent

In order to identify anti-tubercular agents with a novel scaffold, commercial libraries of small organic compounds were screened against a fluorescent strain of Mycobacterium tuberculosis H37Rv, using a dual phenotypic assay. Compounds were assessed again

Synthesis and evaluation of the anticoccidial activity of trifluoropyrido[1,2-a]pyrimidin-2-one derivatives

Screening of our chemical library to discover new molecules exhibiting in vitro activity against the invasion of host cells by Eimeria tenella revealed a lead compound with an IC50 of 15 μM. Structure-activity relationship studies were conducted with 34 newly synthesized compounds to identify more active molecules and enhance in vitro activity against the parasite. Four compounds were more effective in inhibiting MDBK cell invasion in vitro than the lead compound.

Peptide deformylase inhibitors

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.