503536-74-1Relevant articles and documents
The design and SAR of a novel series of 2-aminopyridine based LRRK2 inhibitors
Smith, Garrick P.,Badolo, Lassina,Chell, Victoria,Chen, I-Jen,Christensen, Kenneth Vielsted,David, Laurent,Daechsel, Justus Alfred,Hentzer, Morten,Herzig, Martin Christian,Mikkelsen, Gitte Kobber?e,Watson, Stephen P.,Williamson, Douglas S.
, p. 4500 - 4505 (2017/09/12)
Leucine-rich repeat kinase 2 (LRRK2) has attracted considerable interest as a therapeutic target for the treatment of Parkinson's disease. Compounds derived from a 2-aminopyridine screening hit were optimised using a LRRK2 homology model based on mixed li
A new class of pyrazolopyridine nucleus with fluorescent properties, obtained through either a radical or a Pd arylation pathway from N-azinylpyridinium N-aminides
Abet, Valentina,Nunez, Araceli,Mendicuti, Francisco,Burgos, Carolina,Alvarez-Builla, Julio
scheme or table, p. 8800 - 8807 (2009/04/11)
(Chemical Equation Presented) The synthesis of dipyridopyrazole and pyridopyrazolopyrazine derivatives - both of which incorporate a 3-aryl moiety - can be achieved in moderate yields by intramolecular radical arylation of pyridinium N-aminides using tris(trimethylsilyl)silane and azobisisobutyronitrile. Improved results were obtained on using Pd direct arylation in conjunction with microwave irradiation. A preliminary study into the fluorescent properties of the target compounds is also reported.