503536-77-4

Basic information

• Product Name: 5-[4-(Dimethylamino)phenyl]-2-pyridinamine
• Synonyms: 5-[4-(Dimethylamino)phenyl]-2-pyridinamine;5-(4-(Dimethylamino)phenyl)pyridin-2-amine
• CAS NO: 503536-77-4
• Molecular Formula: C₁₃H₁₅N₃
• Molecular Weight: 213.283
• Mol File: 503536-77-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 383.132 °C at 760 mmHg
• Flash Point: 185.512 °C
• Appearance: /
• Density: 1.133
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-[4-(Dimethylamino)phenyl]-2-pyridinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[4-(Dimethylamino)phenyl]-2-pyridinamine(503536-77-4)
• EPA Substance Registry System: 5-[4-(Dimethylamino)phenyl]-2-pyridinamine(503536-77-4)

Safety Data

• Hazardous Substances Data: 503536-77-4(Hazardous Substances Data)

Usage

General Description

5-[4-(Dimethylamino)phenyl]-2-pyridinamine is a chemical compound with a molecular formula C13H14N4. It is commonly used as a reagent in organic synthesis and pharmaceutical research. 5-[4-(Dimethylamino)phenyl]-2-pyridinamine is a pyridine derivative containing a 4-dimethylaminophenyl group, and it is often used as a precursor in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the creation of fluorescent dyes and imaging agents for biomedical research. The compound has a wide range of applications in the fields of chemistry, medicine, and materials science due to its unique structural properties and reactivity.

InChI:InChI=1/C13H15N3/c1-16(2)12-6-3-10(4-7-12)11-5-8-13(14)15-9-11/h3-9H,1-2H3,(H2,14,15)

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 28611-39-4 4-(dimethylamino)benzene-boronic acid 

Relevant articles and documents

Discovery and in Vivo Anti-inflammatory Activity Evaluation of a Novel Non-peptidyl Non-covalent Cathepsin C Inhibitor

Cathepsin C (Cat C) participates in inflammation and immune regulation by affecting the activation of neutrophil serine proteases (NSPs). Therefore, cathepsin C is an attractive target for treatment of NSP-related inflammatory diseases. Here, the complete discovery process of the first potent "non-peptidyl non-covalent cathepsin C inhibitor"was described with hit finding, structure optimization, and lead discovery. Starting with hit 14, structure-based optimization and structure-activity relationship study were comprehensively carried out, and lead compound 54 was discovered as a potent drug-like cathepsin C inhibitor both in vivo and in vitro. Also, compound 54 (with cathepsin C Enz IC50 = 57.4 nM) exhibited effective anti-inflammatory activity in an animal model of chronic obstructive pulmonary disease. These results confirmed that the non-peptidyl and non-covalent derivative could be used as an effective cathepsin C inhibitor and encouraged us to continue further drug discovery on the basis of this finding.