50358-39-9

Basic information

• Product Name: 6-BROMOQUINOLIN-5-AMINE
• Synonyms: 6-BROMOQUINOLIN-5-AMINE;5-Amino-6-bromoquinoline
• CAS NO: 50358-39-9
• Molecular Formula: C9H7BrN2
• Molecular Weight: 223.1
• Mol File: 50358-39-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 354.398 °C at 760 mmHg
• Flash Point: 168.134 °C
• Appearance: /
• Density: 1.649 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 4.75±0.15(Predicted)
• CAS DataBase Reference: 6-BROMOQUINOLIN-5-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMOQUINOLIN-5-AMINE(50358-39-9)
• EPA Substance Registry System: 6-BROMOQUINOLIN-5-AMINE(50358-39-9)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 50358-39-9(Hazardous Substances Data)

Usage

General Description

6-Bromoquinolin-5-amine is a chemical substance that belongs to the class of quinoline derivatives. It is a brominated derivative of quinolin-5-amine, and its molecular formula is C9H7BrN2. This chemical compound is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various bioactive molecules and pharmaceutical drugs. It also has potential applications in research and development in the fields of medicinal chemistry and drug discovery. The 6-Bromoquinolin-5-amine compound is known for its diverse and versatile chemical properties, making it a valuable building block for the synthesis of new drug candidates and related compounds.

Upstream product

• 5332-25-2 6-bromoquinoline 
• 115071-54-0 6-bromo-5-nitroquinoline-N-oxide 
• 6563-11-7 6-bromoquinoline-N-oxide 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 7647-01-0 hydrogenchloride 
• 98203-04-4 6-bromo-5-nitroquinoline 
• 20377-01-9 5-quinolyl azide 

Relevant articles and documents

Activation of 6-bromoquinoline by nitration: Synthesis of morpholinyl and piperazinyl quinolones

Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-Active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction. Formula parented.

PHOTOLYSIS OF PYRIDYL, QUINOLYL, AND ISOQUINOLYL AZIDES IN HYDROHALOGENOIC ACIDS

Photolysis of 4-azido-pyridine and -quinoline in hydrohalogenoic acids gave the 3-amino-4-halogeno compounds (2) via azirine or azacycloheptatetraene intermediates, whereas their N-oxides (4), under similar conditions, gave the 4-amino-3-halogeno compounds (5) presumably via nitrenium ion intermediates.In the 3-azidoquinoline and 4-azidoisoquinoline series, both free bases (6a, 8a) and N-oxides (6b, 8b) gave similar results to 4-azidopyridine and -quinoline N-oxides (4).