503595-76-4

Basic information

• Product Name: 2-Propyn-1-one, 1-phenyl-3-[tris(1-methylethyl)silyl]-
• CAS NO: 503595-76-4
• Molecular Formula: C18H26OSi
• Molecular Weight: 286.489
• Mol File: 503595-76-4.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 2-Propyn-1-one, 1-phenyl-3-[tris(1-methylethyl)silyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propyn-1-one, 1-phenyl-3-[tris(1-methylethyl)silyl]-(503595-76-4)
• EPA Substance Registry System: 2-Propyn-1-one, 1-phenyl-3-[tris(1-methylethyl)silyl]-(503595-76-4)

Safety Data

• Hazardous Substances Data: 503595-76-4(Hazardous Substances Data)

Upstream product

• 611-73-4 Benzoylformic acid 
• 181934-30-5 1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one 
• 6125-26-4 phenyl(2-phenyl-2,3-dihydrobenzo[d]thiazol-2-yl)methanone 
• 134-81-6 benzil 
• 1074-12-0 phenylglyoxal hydrate 
• 98-86-2 acetophenone 
• 10002-30-9 S-pyridin-2-yl benzenecarbothioate 
• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 
• 108-88-3 toluene 
• 103-82-2 phenylacetic acid 
• 107474-02-2 1-(triisopropylsilyl)-2-(trimethylsilyl)acetylene 
• 100-51-6 benzyl alcohol 
• 100-52-7 benzaldehyde 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1307263-17-7 C₁₉H₂₆Cl₂Si 
• 1307263-00-8 C₁₉H₂₆Br₂Si 
• 1307262-99-2 trans-1,4-diphenyl-1,4-bis(triisopropylsilylethynyl)butatriene 
• 1307262-99-2 cis-1,4-diphenyl-1,4-bis(triisopropylsilylethynyl)butatriene 
• 1353273-75-2 C₂₁H₃₀OSi 
• 1353273-77-4 C₂₄H₃₈OSi₂ 
• 1353273-79-6 C₂₇H₄₄OSi₂ 
• 1353273-81-0 C₂₇H₃₄OSi 
• 263720-76-9 1-phenyl-3-(triisopropylsilyl)prop-2-yn-1-ol 
• 1421518-42-4 {3,18-dihydroxy-6,9,12,15-tetramethoxy-3,6,9,12,15,18-hexaphenyl-20-[tris(propan-2-yl)silyl]icosa-1,4,7,10,13,16,19-heptayn-1-yl}tris(propan-2-yl)silane 
• 1421518-45-7 {3,12-dihydroxy-6,9-dimethoxy-3,6,9,12-tetraphenyl-14-[tris(propan-2-yl)silyl]tetradeca-1,4,7,10,13-pentayn-1-yl}tris(propan-2-yl)silane 
• 1421518-41-3 tris(propan-2-yl)({3,6,9,12-tetraphenyl-14-[tris(propan-2-yl)silyl]tetradeca-3,4,5,9,10,11-hexaen-1,7,13-triyn-1-yl})silane 

Relevant articles and documents

Ynonylation of Acyl Radicals by Electroinduced Homolysis of 4-Acyl-1,4-dihydropyridines

Herein we report the conversion of 4-Acyl-1,4-dihydropyridines (DHPs) into ynones under electrochemical conditions. The reaction proceeds via the homolysis of acyl-DHP under electron activation. The resulting acyl radicals react with hypervalent iodine(III) reagents to form the target ynones or ynamides in acceptable yields. This mild reaction condition allows wider functionality tolerance that includes halides, carboxylates, or alkenes. The synthetic utility of this methodology is further demonstrated by the late-stage modification of complex molecules.

Alkyne derivative as well as preparation method and application thereof (by machine translation)

The invention belongs to the technical field of organic synthesis, and discloses an acetylenic ketone derivative and a preparation method and application thereof. The formula (I) is shown in the structural formula of the alkyne derivative. R1 And R2 Heterocyclyl groups of C1 - C20, halogen, ester, carbonyl, nitro, substituted amino, C5 - C30, or C5 - C30, respectively. To the strategy of nickel catalytic reduction coupling, a carboxylic acid derivative which is widely used in nature is used as a substrate, an alkyne halide is combined as an active alkynylation reagent, and under the condition of room temperature, the universality and the high efficiency method for rapidly constructing various substituted alkynes are obtained. The alkyne compound disclosed by the invention not only can be used as a practical synthesis, but also can be used as a precursor of heterocyclic compounds such as furan, pyrazole, quinoline, pyrimidine and the like. (by machine translation)

Alkynylation of Csp2 (O)–H Bonds Enabled by Photoredox-Mediated Hydrogen-Atom Transfer

The development of new hydrogen-atom transfer (HAT) strategies within the framework of photoredox catalysis is highly appealing for its power to activate a desired C?H bond in the substrate leading to its selective functionalization. Reported here is the first photoredox-mediated hydrogen-atom transfer method for the efficient synthesis of ynones, ynamides, and ynoates with high regio- and chemoselectivity by direct functionalization of Csp2 (O)?H bonds. The broad synthetic application of this method has been demonstrated by the selective functionalization of C(O)?H bonds within complex molecular scaffolds.