5044-21-3Relevant articles and documents
Synthesis method of 1-aminomethyl-1-cyclopropanol
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Paragraph 0033-0037, (2020/08/09)
The invention discloses a synthetic method of 1-aminomethyl-1-cyclopropanol. The synthetic method comprises the following steps: adding a compound C00 into an aqueous potassium carbonate solution to form a first solution; adding an aqueous solution of C01 into the first solution for a reaction; combining organic phases, carrying out cleaning with saline water, and performing drying, filtering andconcentrating to obtain a compound C02; dissolving the compound C02 in tetrahydrofuran to form a second solution; adding tetraisopropyl titanate into the second solution to form a third solution; adding an ethyl magnesium bromide solution into the third solution for a reaction; adding an aqueous ammonium chloride solution into the solution for a quenching reaction; combining organic layers to obtain a compound C03; dissolving the compound C03 into an absolute ethyl alcohol solution to form a fourth solution; adding a sodium hydroxide solution into the fourth solution; adding a hydroxylamine hydrochloride solution into the fourth solution to form a fifth solution; and adding a sodium hydroxide solution into the fifth solution until the pH value is 6-7, and carrying out distilling to removea water phase, thereby obtaining the product, i.e., 1-aminomethyl-1-cyclopropanol. In this way, palladium hydroxide is not used as a catalyst, and synthesis cost is reduced.
CRTH2 MODULATORS
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Page/Page column 46, (2011/06/28)
Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I:
