5044-26-8

Basic information

• Product Name: 2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE
• Synonyms: 2,5-dimethyl-1-(4-methylphenyl)pyrrole
• CAS NO: 5044-26-8
• Molecular Formula: C₁₃H₁₅N
• Molecular Weight: 185.27
• Mol File: 5044-26-8.mol
• Article Data: 52

Chemical Properties

• Boiling Point: 291°Cat760mmHg
• Flash Point: 129.8°C
• Appearance: /
• Density: 0.96g/cm³
• Vapor Pressure: 7.92E-13mmHg at 25°C
• Refractive Index: 1.659
• CAS DataBase Reference: 2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE(5044-26-8)
• EPA Substance Registry System: 2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE(5044-26-8)

Safety Data

• Hazardous Substances Data: 5044-26-8(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE is a chemical compound with the molecular formula C13H15N. It is a pyrrole derivative with a p-tolyl group attached to the 1-position and two methyl groups attached to the 2 and 5 positions of the pyrrole ring. 2,5-DIMETHYL-1-P-TOLYL-1H-PYRROLE is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in drug discovery and development due to its structural features and biological activities. Additionally, it may have uses in the development of new materials and as a chemical intermediate in the manufacturing of various products.

InChI:InChI=1/C25H25N3/c1-17-10-11-18(2)23(15-17)28-25-22(9-5-6-14-26-25)24(27-28)21-13-12-19-7-3-4-8-20(19)16-21/h3-4,7-8,10-13,15-16,27H,5-6,9,14H2,1-2H3

Upstream product

• 625-84-3 2,5-Dimethylpyrrole 
• 106-49-0 p-toluidine 
• 2935-44-6 hexane-2,5-diol 
• 625-86-5 2,5-dimethylfuran 
• 109-49-9 5-Hexen-2-one 
• 99-99-0 1-methyl-4-nitrobenzene 
• 1333-74-0 hydrogen 
• 110-13-4 2,5-hexanedione 
• 628-16-0 hexa-1,5-diyne 

Downstream Products

• 682772-00-5 2-(2,5-dimethyl-1-p-tolyl-1H-pyrrol-3-yl)-2-hydroxy-1-phenylethanone 
• 943903-83-1 2-[2,5-dimethyl-1-(4-methylphenyl)pyrrole-3-carboxamido]-2,3-dihydro-1H-1,2,5-oxadiazolo[3,4-c][1,3,2]diazaphosphole-2-oxide 
• 920953-92-0 1-(1,3-benzothiazol-2-yl)-1-(2,5-dimethyl-1-(4-tolyl)-1H-pyrrol-3-yl)-2,2,2-trifluoroethanol 

Relevant articles and documents

A convenient approach for the synthesis of substituted pyrroles by using phosphoric acid as a catalyst and their photophysical properties

Twenty-three new pyrrole compounds aside from six knowns, including the synthetically challenging tetra- and penta-substituted pyrroles from the corresponding 1,4-dicarbonyl through Paal-Knorr synthesis in the presence of 5% phosphoric acid as the catalyst. Our method is noteworthy for cheap catalyst, uncomplicated experimental setup under air atmosphere, scalability, and excellent yields. The fluorescence of some selected pyrroles was investigated in dilute solution, and we found that all novel pyrroles emit strong blue fluorescences with considerable Stokes shifts.

Crystalline salicylic acid as an efficient catalyst for ultrafast Paal–Knorr pyrrole synthesis under microwave induction

Abstract: In this study, the viability of a wide range of crystalline aromatic and aliphatic carboxylic acids as organocatalysts has been investigated for solvent-free Paal–Knorr pyrrole synthesis under microwave activation. Among these potential catalysts, crystalline salicylic acid proved to be a remarkable catalyst because its efficiency remained high even under low microwave power irradiation or a shorter reaction time for the model reaction. The outstanding catalytic activity of salicylic acid allowed the Paal–Knorr cyclocondensation with a turnover frequency up to 1472?h?1 which is unique in the context of a metal-free homogeneous catalysis. The attractive feature of this organocatalyst is its assistance in ultrafast pyrrole synthesis with no risk of metal contamination. Graphic abstract: [Figure not available: see fulltext.] Synopsis: A green and expeditious protocol for the synthesis of 2,5-dimethylpyrroles via combination of salicylic acid as catalyst (in its solid state) and microwaves has been introduced.

One-pot synthesis of cyclohexylamine and: N -aryl pyrroles via hydrogenation of nitroarenes over the Pd0.5Ru0.5-PVP catalyst

The direct synthesis of cyclohexylamine via the hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (PdxRu1-x) catalysts was studied. The Pd0.5Ru0.5-PVP catalyst was the most effective catalyst for this reaction. The catalyst can be reused and applied for the synthesis of N-aryl pyrroles and quinoxalines from nitrobenzenes.