50521-41-0Relevant articles and documents
Synthesis of functionalized pyrrole and indole derivatives through carbometallation of lithiated double bonds
Fananas, Francisco J.,Granados, Alejandro,Sanz, Roberto,Ignacio, Jose M.,Barluenga, Jose
, p. 2896 - 2907 (2007/10/03)
Bis(2-lithioallyl)amines derived from bis(2-bromoallyl)amines undergo intramolecular carbometallation of a lithiated double bond, giving dilithiated dihydropyrroles. The cyclizations are promoted by N,N,N′,N′-tetramethylethylenediamine (TMEDA). Reaction of these intermediates with electrophiles allows the preparation of some new fused and nonfused five-membered functionalized heterocycles. Although 2-lithioallylamines do not suffer intermolecular carbometallation, dimerization products are obtained with their copper or zirconium derivatives. Finally, the application of this new reaction to 2-lithio-N-(2-lithioallyl)anilines leads to 3-lithiomethylindole derivatives, which are transformed to functionalized indole derivatives by reaction with electrophiles.
A Synthesis of Substituted Pyrrolidines via a Palladium(2+)-Catalyzed Cyclization. An Unusual Approach to a Carbapenem
Trost, Barry M.,Chen, Shyh-Fong
, p. 6053 - 6054 (2007/10/02)
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Synthesis of 1 aryl 3,4 dimethylenepyrrolidines by the thermal elimination of sulfur dioxide
Ottenbrite,Alston
, p. 785 - 790 (2007/10/07)
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