5057-52-3

Basic information

• Product Name: Butyric acid, 4-(o-chlorophenoxy)-
• Synonyms: 4-(2-Chlorophenoxy)butanoic acid; butanoic acid, 4-(2-chlorophenoxy)-
• CAS NO: 5057-52-3
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.6455
• Mol File: 5057-52-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 380.3°Cat760mmHg
• Flash Point: 183.8°C
• Appearance: /
• Density: 1.266g/cm³
• Vapor Pressure: 1.85E-06mmHg at 25°C
• Refractive Index: 1.541
• CAS DataBase Reference: Butyric acid, 4-(o-chlorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butyric acid, 4-(o-chlorophenoxy)-(5057-52-3)
• EPA Substance Registry System: Butyric acid, 4-(o-chlorophenoxy)-(5057-52-3)

Safety Data

• Hazardous Substances Data: 5057-52-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11ClO3/c11-8-4-1-2-5-9(8)14-7-3-6-10(12)13/h1-2,4-5H,3,6-7H2,(H,12,13)

Upstream product

• 20825-71-2 2(3H)-furanone 
• 95-57-8 2-monochlorophenol 
• 111105-19-2 ethyl 4-(2-chlorophenoxy)butanoate 
• 96-48-0 4-butanolide 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 5057-51-2 4-(3-chlorophenoxy)butanoic acid 

Relevant articles and documents

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART). Epigenetic targeted compounds have shown promise as potential latency-reversing agents; however, these drugs have undesirable toxicity and lack specificity for HIV. We utilized a novel HEK293-derived FlpIn dual-reporter cell line, which quantifies specific HIV provirus reactivation (LTR promoter) relative to nonspecific host cell gene expression (CMV promoter), to identify the 5-substituted 2-acylaminothiazole hit class. Here, we describe the optimization of the hit class, defining the functionality necessary for HIV gene activation and for improving in vitro metabolism and solubility. The optimized compounds displayed enhanced HIV gene expression in HEK293 and Jurkat 10.6 latency cellular models and increased unspliced HIV RNA in resting CD4+ T cells isolated from HIV-infected individuals on ART, demonstrating the potential of the 2-acylaminothiazole class as latency-reversing agents.

NOVEL THIOPHENE DERIVATIVES WHICH ARE HM74A AGONISTS

The invention is concerned with novel substituted thiophene derivatives of formula (I) wherein R1 to R8, X, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds are HM74A agonists and can be used as medicaments.