50675-18-8

Basic information

• Product Name: Tetrahydropyran-4-carbaldehyde
• Synonyms: 4-FORMYLTETRAHYDROPYRAN;TETRAHYDRO-2H-PYRAN-4-CARBALDEHYDE;TETRAHYDRO-PYRAN-4-CARBALDEHYDE;TETRAHYDROPYRANYL-4-CARBOXALDEHYDE;Tetrahydro-2H-pyran-4-carboxaldehyde;Tetrahydropyran-4-carboxaldehyde;Tetrahydropyran-4-carboxaldehyde 95%;TETRAHYDRO-PYRAN-4-CARBALDEHYD
• CAS NO: 50675-18-8
• Molecular Formula: C₆H₁₀O₂
• Molecular Weight: 114.14
• Product Categories: Aldehydes;blocks;Heterocycles;Building Blocks;Pyran
• Mol File: 50675-18-8.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 176.921 °C at 760 mmHg
• Flash Point: >23℃
• Appearance: /
• Density: 1.097 g/cm³
• Vapor Pressure: 1.067mmHg at 25°C
• Refractive Index: 1.513
• Storage Temp.: Keep Cold
• CAS DataBase Reference: Tetrahydropyran-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydropyran-4-carbaldehyde(50675-18-8)
• EPA Substance Registry System: Tetrahydropyran-4-carbaldehyde(50675-18-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36-20/21/22
• Safety Statements: 26-36/37-24/25
• RIDADR: 1993
• Hazardous Substances Data: 50675-18-8(Hazardous Substances Data)

Usage

Description

Tetrahydropyran-4-carbaldehyde, also known as 4-Formyltetrahydropyran, is a colorless liquid with unique chemical properties. It is a derivative of tetrahydropyran, a heterocyclic compound, and features an aldehyde functional group. Tetrahydropyran-4-carbaldehyde is known for its role in the synthesis of various heterocyclic compounds, which have significant applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
Tetrahydropyran-4-carbaldehyde is used as a key intermediate in the synthesis of heterocyclic compounds for pharmaceutical applications. These heterocyclic compounds are essential in the development of new drugs and therapeutic agents, targeting a wide range of medical conditions.
Used in Chemical Industry:
In the chemical industry, Tetrahydropyran-4-carbaldehyde serves as a versatile building block for the creation of various organic compounds. Its aldehyde functional group allows for a wide range of chemical reactions, making it a valuable component in the synthesis of complex molecules and materials.
Used in Research and Development:
Tetrahydropyran-4-carbaldehyde is also utilized in research and development settings, where it is employed to study the properties and reactivity of heterocyclic compounds. This knowledge contributes to the advancement of chemical science and the discovery of novel applications for these compounds.

InChI:InChI=1/C6H10O2/c7-5-6-1-3-8-4-2-6/h5-6H,1-4H2

Upstream product

• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 50-00-0 formaldehyd 
• 96835-17-5 ethyl tetrahydro-2H-pyran-4-carboxylate 
• 4295-99-2 tetrahydro-2H-pyran-4-carbonitrile 
• 6192-52-5 p-toluenesulfonic acid monohydrate 
• 144-55-8 sodium hydrogencarbonate 
• 101765-10-0 tetrahydro-4-(methoxymethylene)-2H-pyran 
• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 2081-44-9 Tetrahydro-pyran-4-ol 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 14774-37-9 (tetrahydro-2H-pyran-4-yl)methanol 
• 185-72-8 1,6-dioxa-spiro[2.5]octane 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 

Downstream Products

• 53284-84-7 2-amino-2-(oxan-4-yl)acetic acid 
• 216087-92-2 rac-(tetrahydro-2H-pyran-4-yl)(phenyl)methanol 
• 98337-80-5 tetrahydro-pyran-4-carbaldehyde semicarbazone 
• 104912-18-7 tetrahydro-pyran-4-carbaldehyde-(2,4-dinitro-phenylhydrazone) 
• 99228-16-7 tetrahydropyran-4-yl-acrylic acid ethyl ester 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 745053-02-5 (E)-ethyl 2-(4-methanesulfonylphenyl)-3-(tetrahydropyran-4-yl)acrylate 
• 790223-63-1 4-(tetrahydro-pyran-4-ylmethyl)-piperazine-1-carboxylic acid benzyl ester 
• 745053-10-5 ethyl 3-(tetrahydropyran-4-yl)-2-(4-[1,2,3]triazol-1-ylphenyl)acrylate 
• 910910-88-2 4-((3-methyl-3H-imidazol-4-ylmethyl)-{2-[(tetrahydropyran-4-ylmethyl)amino]ethyl}amino)benzonitrile 
• 1190854-84-2 4-{7-[(cyclopropylmethyl)(tetrahydro-2H-pyran-4-ylmethyl)amino]-6-methoxypyrazolo[5,1-b][1,3]thiazol-3-yl}-3,5-dimethoxybenzonitrile 
• 1190854-85-3 > N-(Cyclopropylmethyl)-6-methoxy-N-(tetrahydro-2H-pyran-4-ylmethyl)-3-(2,4,6-trimethoxyphenyl)-pyrazolo[5,1-b][1,3]thiazole-7-amine 
• 1221888-41-0 (3,5-dimethoxyphenyl)(tetrahydropyran-4-yl)methanol 
• 1228779-98-3 4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide 

Relevant articles and documents

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine

The invention relates to the technical field of organic synthesis. For solving the problems that a conventional synthesis method of 4-ethynyl-tetrahydropyran and 4-ethynyl piperidine is complex in operation, high in cost and unsuitable for industrial production in the prior art, the invention provides a synthesis method of 4-ethynyl-tetrahydropyran or 4-ethynyl piperidine, wherein the synthesis method comprises the following steps: carrying out Wittig reaction on carbonyl of a compound represented by the formula (I) and phosphorus ylide salt under the action of a strong alkali to generate a compound represented by the formula (II), wherein the reaction temperature is 0-50 DEG C; (2) hydrolyzing the compound represented by the formula (II) to generate a compound represented by the formula (III), wherein the reaction temperature is 20-60 DEG C; (3) carrying out a Corey-Fuchs reaction on the compound represented by the formula (III) to obtain a compound represented by the formula (IV), wherein the reaction temperature is -20 to 40 DEG C; and (4) carrying out a reaction of the compound represented by the formula (IV) with a strong alkali, and carrying out a reaction with a silica reagent to generate a compound represented by the formula (V), wherein the reaction temperature is -70 to 20 DEG C. The method has the advantages of simple and accessible raw materials, low cost, simple synthesis steps and high yield, and is suitable for laboratory small-scale preparation and industrial production.

Aromatic-ring-containing compound, preparation method thereof, pharmaceutical composition and application thereof

The invention discloses an aromatic-ring-containing compound, a preparation method thereof, a pharmaceutical composition and application. The present invention provides the aromatic-ring-containing compound represented by a formula 1, a pharmaceutically acceptable salt thereof, a stereoisomer thereof, a tautomer thereof or a solvate thereof, and the aromatic-ring-containing compound can be effectively bounded to bromodomains of BRD4, BRD3, BRD2, and BRDT in BET family to regulate transcription of downstream gene c-myc and related target genes of the c-myc so as to regulate downstream signalingpathways to play specific roles including treatment of diseases such as inflammatory diseases, cancer, and AIDS. Some of the compounds have high activity, and have good cell activity and metabolic stability, so that the compounds can be an effective drug for treating tumors.