50685-03-5

Basic information

• Product Name: 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-
• Synonyms: N-Carbobenzoxy-2,3-dihydro-butysinaethylester;(Z)-2-Benzyloxycarbonylamino-but-2-enoic acid ethyl ester
• CAS NO: 50685-03-5
• Molecular Formula: C14H17NO4
• Molecular Weight: 263.28900
• Mol File: 50685-03-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-(50685-03-5)
• EPA Substance Registry System: 2-Butenoic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester, (Z)-(50685-03-5)

Safety Data

• Hazardous Substances Data: 50685-03-5(Hazardous Substances Data)

Upstream product

• 15933-07-0 Ethyl 2-oxobutanoate 
• 621-84-1 O-benzyl carbamate 
• 75-07-0 acetaldehyde 
• 295365-34-3 ethyl benzyloxycarbonylamino(toluene-4-sulfonyl)acetate 
• 79-24-3 Nitroethane 
• 71385-53-0 amino-crotonic acid ethyl ester 
• 501-53-1 benzyl chloroformate 
• 24066-82-8 ethyl 2-isothiocyanatoacetate 

Downstream Products

• 63655-79-8 Cbz-(Z)-ΔBut-Gly-OEt 
• 72015-57-7 (Z)-2-(benzyloxycarbonylamino)but-2-enoic acid 

Relevant articles and documents

A new synthetic method for the preparation of α,β-didehydroamino acid derivatives by means of a wittig-type reaction. Syntheses of (2S, 4S)- and (2R, 4R)-4-hydroxyprolines

Ethyl N-Boc- and N-Z-α-tosylglycinates were reacted with a variety of aldehydes in the presence of tributylphosphine and a base to afford the corresponding α,β-didehydroamino acid derivatives with high (Z)-selectivity in good yields. Moreover, ethyl (4S)- and (4R)-2-(N-Boc-amino)-4,5-isopropylidenedioxy-2-pentenoates prepared by the present method were converted to (2S, 4S)- and (2R, 4R)-4-hydroxyprolines, respectively.

Dehydrooligopeptides. I. The facile coupling of α-amino acids with α-dehydroamino acids to dehydrodipeptides

-