50735-77-8

Basic information

• Product Name: α,α-dichlorophenylacetaldehyde
• Synonyms: α,α-dichlorophenylacetaldehyde
• CAS NO: 50735-77-8
• Molecular Weight: 189.041
• Mol File: 50735-77-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: α,α-dichlorophenylacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-dichlorophenylacetaldehyde(50735-77-8)
• EPA Substance Registry System: α,α-dichlorophenylacetaldehyde(50735-77-8)

Safety Data

• Hazardous Substances Data: 50735-77-8(Hazardous Substances Data)

Upstream product

• 60-12-8 2-phenylethanol 
• 122-78-1 phenylacetaldehyde 
• 98-07-7 Benzotrichlorid 
• 68-12-2 N,N-dimethyl-formamide 
• 107-31-3 Methyl formate 
• 96-09-3 styrene oxide 

Downstream Products

• 1074-12-0 phenylglyoxal hydrate 
• 157062-55-0 1-Chlor-1-phenyl-2-(p-tolylsulfonylazo)ethen 
• 77572-27-1 (E)-4,4-Dichloro-4-phenyl-but-2-enoic acid methyl ester 
• 77572-37-3 (E)-4,4-Dichloro-4-phenyl-but-2-enenitrile 
• 96165-32-1 4-(dichlorophenylmethyl)-2-oxetanone 
• 96165-31-0 4-(dichlorophenylmethyl)-2-oxetanone 

Relevant articles and documents

Synthesis of trans-2-Substituted Cyclopropylamines from α-Chloroaldehydes

Cyclopropylamines are prevalent in pharmaceuticals and agrochemicals. Herein, we report the synthesis of trans-2-substituted cyclopropylamines in high diastereoselectivity from readily available α-chloroaldehydes. The reaction proceeds via trapping of an electrophilic zinc homoenolate with an amine followed by ring closure to generate the cyclopropylamine. We have also observed that cyclopropylamine cis/trans-isomerization occurs in the presence of zinc halide salts and that this process can be turned off by the addition of a polar aprotic cosolvent.

Use of phenylselenium trichloride for simple and rapid preparation of α-phenylselanyl aldehydes and ketones

α-Phenylselanyl aldehydes are prepared on a large scale by reaction of PhSeCl3 with the corresponding aldehydes in acetonitrile without isolation of the intermediate dichloro adducts. This method has been applied to α-phenylselanyl ketones deri

2,2-DICHLOROALDEHYDES FROM ALDEHYDES AND ALCOHOLS BY CHLORINATION IN DIMETHYLFORMAMIDE

A method is described for the synthesis of α,α-dichloroaldehydes, free from monochloroaldehyde, by chlorination of aldehydes or alcohols in dimethylformamide at 40-90 deg C.Results are reported for : (yield percent) propanal (90), butanal (78), pentanal (78), 3-methylbutanal (90), propanol (64), butanol (78), 3-methylbutanol (52), pentanol (66), 3,3-dimethylbutanol (86), hexanol (66), 2-phenylethanol (51), 3-phenylpropanol (54), 1,5-pentanediol , 1,6-hexanediol .Oxidative conversion (KMnO4, K2Cr2O7, H2O2-NaHCO3) into α,α-dichlorocarboxylic acids and methyl esters is discussed.