507476-77-9

Basic information

• Product Name: 2,6-dicyano-3-trifluoromethyl-5-methylaniline
• Synonyms: 2,6-dicyano-3-trifluoromethyl-5-methylaniline
• CAS NO: 507476-77-9
• Molecular Weight: 225.173
• Mol File: 507476-77-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-dicyano-3-trifluoromethyl-5-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dicyano-3-trifluoromethyl-5-methylaniline(507476-77-9)
• EPA Substance Registry System: 2,6-dicyano-3-trifluoromethyl-5-methylaniline(507476-77-9)

Safety Data

• Hazardous Substances Data: 507476-77-9(Hazardous Substances Data)

Upstream product

• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 109-77-3 malononitrile 

Downstream Products

• 853052-94-5 ethyl 3-amino-1-benzyl-7-cyano-6-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylate 
• 853053-03-9 3-amino-7-(aminocarbonyl)-1-benzyl-6-methyl-4-(trifluoromethyl)-1H-indole-2-carboxylic acid 
• 853052-86-5 2-(benzylamino)-4-methyl-6-(trifluoromethyl)isophthalonitrile 
• 853052-85-4 2-(ethylamino)-4-methyl-6-(trifluoromethyl)isophthalonitrile 
• 853052-84-3 4-methyl-2-(methylamino)-6-(trifluoromethyl)isophthalonitrile 
• 917234-36-7 2-amino-3-[imino(phenyl)methyl]-4-methyl-6-(trifluoromethyl)benzonitrile 

Relevant articles and documents

A simple and facile method for the synthesis of novel 5/7 triflouromethyl-substituted 4(3H)-quinazolone regioisomers

The unsymmetrical 1,3-diketones 1 on reaction with malononitrile is resulted an interesting trifunctional intermediates 2 and 3. The intermediate 2 is hydrolyzed to give 2,6-dicarboxamido aniline 4 which on cyclisation gave two regioisomers of 1,2-dihydro-4(3H)-quinazolinones 5 and 6. The effect of substituents on compound 4 is characteristic for formation of regioisomers in different proportions. Each regioisomer on dehydrogenation under mild condition using active MnO2 gave corresponding 4(3H)-quinazolones 7 and 8, respectively.