508-84-9 Usage
Description
Divaside, also known as Divasidum, is a cardiac glycoside compound derived from the seeds of the Apocynaceae plant Strophanthus divaricatus, which is also known as Gelsemium elegans and Morinda umbellata L. This plant has been recorded in the Flora of China and has been traditionally used in Chinese medicine for various applications.
Uses
Used in Traditional Chinese Medicine:
Divaside is used as a traditional Chinese medicine for treating itching and tinea capitis, as suggested by "Bencaoqiuyuan". It is also used for treating sore, congestion, malignant ulcers, and bruises, as recommended by "Lu Chuan Materia Medica" and "Lingnan herbal medicine".
Used in Pharmaceutical Industry:
In China, Divaside has been developed into an injection for the treatment of heart failure. It is also found in other parts of the Strophanthus divaricatus plant, such as roots, stems, and leaves, along with other types of cardiac glycosides like decogenin, sarmentogenin, sarmutogenin, and bipindogenin.
History
A white amorphous saponin was first extracted from the seeds of Strophanthus divari_x005fcatus in 1940, and the content is 1.8%. Strophanthiline A, B, and C were then identified. Its effect is about two-thirds of that of strophanthin K.?Then, divaricoside (content
0.46%) and caudoside (content 0.19%) were identified in 1953 and 1954 .
Indications
This product is included in the Pharmacopoeia of the People’s Republic of China
(1963).
Divasidum injection can treat congestive heart failure and myocardial
infarction.
Pharmacology
The cardiotonic action of divasidum is similar to strophanthidin . The positive
inotropic action of strophanthidin at the high concentration is achieved by inhibiting
Na+-K+-ATPase activity. Divasidum increases the calcium ion concentration in ventricular myocytes, and this effect is dependent on the T-type calcium channels,
L-type calcium channels, and Na+-Ca2+ exchange . Another study shows that
divasidum has a diuretic effect and sedative effect, and it is similar to strophanthin
K . Studies have also shown that the diuretic mechanism of divasidum is the
direct effect of the cardiac glycoside on the kidney, so that water and chlorine reabsorption in the renal tubules decreased, while the nitrogen excretion increased. In
addition, similar as strophanthin K, divasidum is able to excite uterine smooth muscle. Six new cardiac glycosides that were isolated from the ethanol extract of
Strophanthus divaricatus (Roupellina boivinii) grown in Africa inhibit the proliferation of human ovarian cancer cell line A2780 . One study in cats suggested that
oral administration of divasidum did not induce drug accumulation after 5?days.
Clinical Use
It was observed that among the 22 patients with congestive heart failure, divasidum
treatment displayed good therapeutic effect in 14 patients. In another report, divasidum treatment of congestive heart failure in 58 cases, 39 cases have good results.
However, fast injection induces side effects . The current clinical application of
the divasidum preparation is divasidum injection, which is a mixture of divasidum
and divostroside.
Check Digit Verification of cas no
The CAS Registry Mumber 508-84-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 8 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 508-84:
(5*5)+(4*0)+(3*8)+(2*8)+(1*4)=69
69 % 10 = 9
So 508-84-9 is a valid CAS Registry Number.
InChI:InChI=1/C30H46O8/c1-16-27(33)23(35-4)13-25(37-16)38-19-7-9-28(2)18(12-19)5-6-21-26(28)22(31)14-29(3)20(8-10-30(21,29)34)17-11-24(32)36-15-17/h11,16,18-23,25-27,31,33-34H,5-10,12-15H2,1-4H3/t16-,18+,19-,20+,21+,22+,23-,25-,26+,27-,28-,29+,30-/m0/s1