508-88-3 Usage
Description
(17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide, also known as Digoxigenin, is a steroidal compound derived from the plant Digitalis purpurea, commonly referred to as foxglove. It is a cardiac glycoside with a molecular structure that includes hydroxyl groups at the 3α and 14 positions, and a unique enolide ring system. (17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide has been utilized in the medical field for its therapeutic effects on heart conditions, as well as for its applications in molecular biology and potential anti-inflammatory and anti-cancer properties.
Uses
Used in Pharmaceutical Industry:
(17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide is used as a therapeutic agent for the treatment of congestive heart failure and arrhythmias. It functions by inhibiting the sodium-potassium pump in the cell membrane, which results in increased intracellular calcium levels, thereby enhancing cardiac contractility and reducing heart rate.
Used in Molecular Biology:
In the field of molecular biology, (17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide serves as a valuable tool for the detection and localization of nucleic acids. Its unique properties allow for specific interactions with biological molecules, making it useful in various diagnostic and research applications.
Used in Anti-inflammatory and Anti-cancer Research:
(17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide is also being explored for its potential anti-inflammatory and anti-cancer properties. Its ability to modulate cellular processes suggests that it may have applications in treating inflammatory conditions and inhibiting the growth of cancer cells.
However, due to the risk of toxicity and overdose associated with (17α)-3α,14-Dihydroxy-5β-card-20(22)-enolide, it is crucial that its use is carefully managed and monitored under medical supervision to ensure patient safety and effectiveness.
Check Digit Verification of cas no
The CAS Registry Mumber 508-88-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 508-88:
(5*5)+(4*0)+(3*8)+(2*8)+(1*8)=73
73 % 10 = 3
So 508-88-3 is a valid CAS Registry Number.
InChI:InChI=1/C23H34O4/c1-21-8-5-16(24)12-15(21)3-4-19-18(21)6-9-22(2)17(7-10-23(19,22)26)14-11-20(25)27-13-14/h11,15-19,24,26H,3-10,12-13H2,1-2H3/t15-,16+,17+,18+,19-,21+,22-,23+/m1/s1
508-88-3Relevant articles and documents
BIOTRANSFORMATION OF DIGITOXIGENIN BY CELL SUSPENSION CULTURES OF STROPHANTHUS DIVARICATUS
Kawaguchi, Kiichiro,Hirotani, Masao,Furuya, Tsutomu
, p. 1503 - 1506 (2007/10/02)
Eight compounds, including a new compound (3-epi-17βH-gitoxigenin) were isolated as biotransformation products of digitoxigenin by cell suspension cultures of Strophanthus divaricatus.At the same time, three products were identified by TLC and HPLC. 16β-Hydroxylation and isomerization of the 17β-butenolide ring of digitoxigenin molecule were demonstrated using this cell suspension culture. Key Word Index - Strophanthus divaricatus; Apocynaceae; biotransformation; 16β-hydroxylation; isomerization of 17β-butenolide ring; cardenolides; digitoxigenin; 17βH-gitoxigenin; 3-epi-17βH-gitoxigenin.
Studies on Cerbera. V. Minor glycosides of 17α-digitoxigenin from the stems of genus Cerbera
Yamauchi,Abe,Wan
, p. 4993 - 4995,4993-4995 (2007/10/02)
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Potential anticancer agents. V. Cardiac glycosides of Asclepias albicans (Asclepiadaceae)
Koike,Bevelle,Talapatra,Cordell,Farnsworth
, p. 401 - 405 (2007/10/02)
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