50826-72-7

Basic information

• Product Name: Propanoic acid, 3-(acetylthio)-2-[(acetylthio)methyl]-
• CAS NO: 50826-72-7
• Molecular Formula: C8H12O4S2
• Molecular Weight: 236.313
• Mol File: 50826-72-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-(acetylthio)-2-[(acetylthio)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-(acetylthio)-2-[(acetylthio)methyl]-(50826-72-7)
• EPA Substance Registry System: Propanoic acid, 3-(acetylthio)-2-[(acetylthio)methyl]-(50826-72-7)

Safety Data

• Hazardous Substances Data: 50826-72-7(Hazardous Substances Data)

Upstream product

• 56140-22-8 3-(acetylthio)-2-methenyl-1-propanoic acid 
• 507-09-5 tiolacetic acid 
• 41459-42-1 3-bromo-2-(bromomethyl)propionic acid 
• 10387-40-3 potassium thioacetate 
• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 68-11-1 mercaptoacetic acid 
• 507-09-5 thioacetic acid 

Downstream Products

• 67819-04-9 N-[(2-Acetylthiomethyl)-3-(acetylthio)propanoyl]-L-proline 
• 7634-96-0 3-mercapto-2-(mercaptomethyl)propanoic acid 

Relevant articles and documents

Lead generation of 1,2-dithiolanes as exon 19 and exon 21 mutant EGFR tyrosine kinase inhibitors

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Properties of dihydroasparagusic acid and its use as an antidote against mercury(II) poisoning

Dihydroasparagusic acid is the first naturally occurring dimercaptanic compound that was isolated in 1948 from Asparagus concentrate. Although several synthetic procedures were proposed in the past decades for this natural substance, most of its chemical properties remain unstudied. In this work the capacity of the acid to act as an antidote against mercury(II) toxicity was evaluated in a simple biological model system, Saccharomyces cerevisiae, and is explained by the formation of a precipitate between mercury(II) and dihydroasparagusic acid. The precipitate was analyzed and studied. The solubility was determined by measuring in equilibrated solutions either the concentration of the total mercury(II) present in solution or the free concentration of hydrogen ions. The protonation constants were determined at 25 C and in 1.00 M NaCl, as constant ionic medium, by means of potential difference measurements of a galvanic cell with a glass electrode. The experimental data are explained by proposing the chemical composition of the precipitate and the value of its solubility product. As the solubility of the precipitate increases by increasing the concentration of dihydroasparagusic acid, the further formation of a complex between mercury(II) and dihydroasparagusic acid is assumed. Graphical abstract: [Figure not available: see fulltext.]

Synthesis of Asparagusic Acid Modified Lysine and its Application in Solid-Phase Synthesis of Peptides with Enhanced Cellular Uptake

Cyclic disulfides, such as asparagusic acid, enhance the uptake of a variety of cargoes into live cells. Here, we report a robust and scalable synthesis of an asparagusic acid modified lysine. This amino acid can be used in solid-phase peptide synthesis. We confirmed that incorporation of this building block into the sequence of a peptide increases its cellular uptake substantially.

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.