50830-38-1

Basic information

• Product Name: 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol
• Synonyms: 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol
• CAS NO: 50830-38-1
• Molecular Weight: 537.957
• Mol File: 50830-38-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol(50830-38-1)
• EPA Substance Registry System: 1-[4,4-bis(4-fluorophenyl)butyryl]-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol(50830-38-1)

Safety Data

• Hazardous Substances Data: 50830-38-1(Hazardous Substances Data)

Upstream product

• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 
• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 21928-40-5 1-ethoxycarbonyl-4-(3-trifluoromethyl-4-chlorophenyl)-4-piperidinol 
• 445-01-2 5-bromo-2-chlorobenzotrifluoride 
• 21928-50-7 4-[4-chloro-3-trifluoromethylphenyl]-4-piperidinol 
• 20662-52-6 4,4-bis(4-fluorophenyl)butanoic acid 
• 462-06-6 fluorobenzene 
• 51787-96-3 5-(4-fluorophenyl)dihydrofuran-2(3H)-one 

Downstream Products

• 26864-56-2 penfluridol 

Relevant articles and documents

Penfluridol preparation method

The invention discloses a penfluridol preparation method. The penfluridol preparation method includes the following steps of 1), subjecting succinic anhydride and fluorobenzene to Friedel-Crafts reaction prior to acid decomposition, and collecting a compound from the formula 2) as is shown in the description; 2), putting the compound in a solvent to collect a compound in formula 3) as is shown in the description in a solvent reduced through a reducing agent; 3), putting the compound into the fluorobenzene to perform the Friedel-Crafts reaction to collect a compound in the formula 4) as is shown in the description; subjecting the compound and ethyl chloroformate to action to generate a compound in formula 5) as is shown in the description; 5), subjecting the compound and a compound shown in formula (XVII) to reaction prior to hydrolyzation to collect a compound in formula 6) as is shown in the description; 6), performing reduction with the reducing agent prior to hydrolyzing a reduction product and then collecting penfluridol (I). The penfluridol preparation method is high in yield, low in cost, moderate in reaction condition, short in circuit, proper for industrial production, low in three wastes, easy to treat and suitable for industrial production.