50845-77-7

Basic information

• Product Name: ethyl 2-[(4-methoxyphenyl)amino]acetate
• Synonyms: ethyl 2-[(4-methoxyphenyl)amino]acetate;2-[(4-methoxyphenyl)amino]acetic acid ethyl ester;ethyl 2-[(4-methoxyphenyl)amino]ethanoate;ethyl N-(4-methoxyphenyl)glycinate
• CAS NO: 50845-77-7
• Molecular Formula: C₁₁H₁₅NO₃
• Molecular Weight: 209.2417
• Mol File: 50845-77-7.mol
• Article Data: 63

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: ethyl 2-[(4-methoxyphenyl)amino]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[(4-methoxyphenyl)amino]acetate(50845-77-7)
• EPA Substance Registry System: ethyl 2-[(4-methoxyphenyl)amino]acetate(50845-77-7)

Safety Data

• Hazardous Substances Data: 50845-77-7(Hazardous Substances Data)

Usage

Description

Ethyl 2-[(4-methoxyphenyl)amino]acetate is an organic compound that features a unique structure with an ethyl ester group, an amino group attached to a 4-methoxyphenyl ring, and an acetate moiety. ethyl 2-[(4-methoxyphenyl)amino]acetate is known for its potential reactivity and versatility in chemical synthesis, particularly in the formation of amino acid derivatives.

Uses

Used in Pharmaceutical Industry:
Ethyl 2-[(4-methoxyphenyl)amino]acetate is used as a reactant for the synthesis of amino acid derivatives, which are crucial in the development of new pharmaceutical compounds. ethyl 2-[(4-methoxyphenyl)amino]acetate plays a significant role in the copper-catalyzed cross-dehydrogenative coupling of ketones with glycine derivatives, a method that allows for the efficient and selective formation of these important building blocks in drug discovery and medicinal chemistry.
Used in Chemical Research:
In the field of chemical research, ethyl 2-[(4-methoxyphenyl)amino]acetate serves as a valuable intermediate for the preparation of various organic compounds and materials. Its unique structure allows for further functionalization and modification, making it a useful tool for exploring new chemical reactions and developing novel synthetic pathways.
Used in Material Science:
Ethyl 2-[(4-methoxyphenyl)amino]acetate may also find applications in material science, particularly in the development of new polymers and materials with specific properties. ethyl 2-[(4-methoxyphenyl)amino]acetate's ability to form amino acid derivatives can contribute to the creation of biocompatible materials, sensors, or other advanced materials with tailored characteristics for various applications.

Upstream product

• 64-17-5 ethanol 
• 22094-69-5 N-(4-methoxyphenyl)glycine 
• 104-94-9 4-methoxy-aniline 
• 924-44-7 glyoxylic acid ethyl ester 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 105-36-2 ethyl bromoacetate 
• 109-92-2 ethyl vinyl ether 
• 623-73-4 diazoacetic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 1152-75-6 N,N'-bis(4-methoxyphenyl)iminoformamide 
• 100-17-4 para-methoxynitrobenzene 
• 459-73-4 GlyOEt*HCl 
• 623-33-6 glycine ethyl ester hydrochloride 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 126111-19-1 [((S)-2-Acetoxy-6-benzyloxycarbonylamino-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid ethyl ester 
• 79476-73-6 2-((4-methoxyphenyl)amino)acetohydrazide 
• 126110-43-8 [{(S)-6-Amino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(4-methoxy-phenyl)-amino]-acetic acid 
• 126110-95-0 [((S)-6-Benzyloxycarbonylamino-2-hydroxy-hexanoyl)-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester 
• 126110-72-3 [{(S)-6-Benzyloxycarbonylamino-2-[hydroxy-(4-phenyl-butyl)-phosphinoyloxy]-hexanoyl}-(4-methoxy-phenyl)-amino]-acetic acid benzhydryl ester 
• 203790-61-8 N-(4-methoxyphenyl)-2-[(2R,3R)-2,3-epoxybutyramidyl]acetic acid ethyl ester 
• 115276-75-0 ethyl (E)-2-(p-methoxyphenylimino)acetate 
• 692733-26-9 ethyl 2-((4-methoxyphenyl)-amino)-4-oxopentanoate 
• 1443300-06-8 ethyl 3,4-bis((diethoxyphosphoryl)oxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate 
• 1443300-18-2 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-methoxypropanoate) 
• 1443300-22-8 2-(dimethylcarbamoyl)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-3,4-diyl bis(3-(2-methoxyethoxy)-2,2-dimethylpropanoate) 
• 1443300-50-2 ethyl 3-(benzyloxy)-5-(dimethylcarbamoyl)-4-hydroxy-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate 
• 1443300-51-3 ethyl 3-(benzyloxy)-4-(((bis(benzyloxy)phosphoryl)oxy)methoxy)-5-(dimethylcarbamoyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate 

Relevant articles and documents

On the Regioselectivity of 4-Nitroanisole Photosubstitution with Primary Amines. A Mechanistic and Theoretical Study

4-Nitroanisole photoreacts with n-hexylamine and ethyl glycinate, giving rise to regioselective methoxy and nitro group photosubstitution, respectively.Mechanistic evidence indicates that the latter is produced through a SN23Ar*

Reductive Amination Revisited: Reduction of Aldimines with Trichlorosilane Catalyzed by Dimethylformamide─Functional Group Tolerance, Scope, and Limitations

Aldimines, generated in situ from aliphatic, aromatic, and heteroaromatic aldehydes and aliphatic, aromatic, and heteroaromatic primary or secondary amines, can be reduced with trichlorosilane in the presence of dimethylformamide (DMF) as an organocatalys

Design, synthesis and biological evaluation of oxime lacking Psammaplin inspired chemical libraries as anti-cancer agents

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro. Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro.