50892-50-7Relevant articles and documents
Reaction of 6-Methyl-2-Thiouracil and 6-Phenyl-2-Thiouracil with Chloro-β-Dicarbonyl and Bromo-β-Dicarbonyl Compounds and Their Nitrile Analogs
Yavolovskii,Ivanov, Yu. E.,Fonari,Croitor,Grishchuk,Ivanova, R. Yu.,Kamalov
, p. 2030 - 2035 (2016)
Derivatives of 2-methylidene-1,3-dihydropyrimidin-4-ones 2a, 2b, 2c, 2d, 2e, 2f, 2g were synthesized by interaction of 6-methyl-2-thiouracil and 6-phenyl-2-thiouracil 1a, 1b with some activated halogenides: diethyl bromomalonate, ethyl 2-chloro-3-oxobutanoate, ethyl 2-bromocyanoacetate, 2-bromo-5,5-dimethylcyclohexan-1,3-dione, and bromomalononitrile. The boiling of 1a with ethyl 2-bromocyanoacetate in mixture of ethanol and EtONa results in intramolecular cyclization and formation of thiazolo[3,2-a]pyrimidin-5-one 3. Interaction of 1a with 3-chloropentane-2,4-dione and 2-bromo-1,3-diphenylpropane-1,3-dione yielded corresponding S-substituted thiopyrimidines 4a,4b. In general, the products of 1b S-alkylation are less prone to sulfur extrusion. Reaction of 1b with diethyl bromomalonate in the absence of EtONa stops at the S-alkylation step, while in the presence of EtONa in ethanol or PPh3in dioxane 2-(ethoxycarbonylmethyl)thio-6-phenyl-1,3-dihydropyrimidin-4(1H)-one 6 is formed exclusively. Molecular structure and crystal structure of 2-(1,1-diethoxycarbonylmethyliden)-6-methyl-1,3-dihydropyrimidin-4(1H)-one 2a are discussed.
NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM
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Page/Page column 262-263, (2008/06/13)
The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.
2-PYRIMIDINYLTHIO)ALKANOIC ACIDS, ESTERS, AMIDES AND HYDRAZIDES
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, (2008/06/13)
(2-Pyrimidinylthio)alkanoic acid, esters, amides and hydrazides as well as various 4- and 6-substituted derivatives thereof as depicted by the structural formula: SPC1 In which R and R2 are independently --H or lower alkyl; R1 is --H