50903-47-4Relevant articles and documents
Synthesis and Biological Evaluation of a Valinomycin Analog Bearing a Pentafluorophenyl Active Ester Moiety
D'Accolti, Lucia,Denora, Nunzio,La Piana, Gianluigi,Marzulli, Domenico,Siwy, Zuzanna S.,Fusco, Caterina,Annese, Cosimo
, p. 12646 - 12650 (2015)
A valuable analog of the K+-ionophore valinomycin (1), bearing a pentafluorophenyl ester moiety, has been obtained by selective reaction between the tertiary hydroxyl moiety of analog 2 (available from valinomycin hydroxylation) and the isocyanate group of pentafluorophenyl N-carbonyl glycinate (3) catalyzed by bis(N,N-dimethylformamide)dichlorodioxomolybdenum(VI). LC-HRMS studies show that analog 4 undergoes easy derivatization under mild conditions by reaction with OH- and NH2-containing compounds. Mitochondrial depolarization assays suggest that 4 acts as a K+-ionophore, provided that the glycine carboxyl group is appropriately masked.
Influence of the dipeptide linker configuration on the activity of PSMA ligands
Uspenskaya, Anastasiya A.,Machulkin, Alexey E.,Nimenko, Ekaterina A.,Shafikov, Radik R.,Petrov, Stanislav A.,Skvortsov, Dmitry A.,Beloglazkina, Elena K.,Majouga, Alexander G.
, p. 756 - 759 (2021/01/12)
Selective ligands of an urea-based prostate specific membrane antigen with a phenylalanine/tyrosine-based dipeptide linker and with a mingled chiral centers configuration and/or substituted aromatic fragments were prepared in seven steps by liquid- and in
Synthesis of conjugates between oxazolidinone antibiotics and a pyochelin analogue
Paulen, Aurélie,Hoegy, Fran?oise.,Roche, Béatrice,Schalk, Isabelle J.,Mislin, Ga?tan L.A.
supporting information, p. 4867 - 4870 (2017/09/27)
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium responsible for severe infections, and it is naturally resistant to many clinically approved antibiotic families. Oxazolidinone antibiotics are active against many Gram-positive bacteria, but
