50906-12-2

Basic information

• Product Name: 2-Propenoyl chloride, 3-[4-(acetyloxy)-3-methoxyphenyl]-
• CAS NO: 50906-12-2
• Molecular Formula: C12H11ClO4
• Molecular Weight: 254.67
• Mol File: 50906-12-2.mol
• Article Data: 73

Chemical Properties

• CAS DataBase Reference: 2-Propenoyl chloride, 3-[4-(acetyloxy)-3-methoxyphenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoyl chloride, 3-[4-(acetyloxy)-3-methoxyphenyl]-(50906-12-2)
• EPA Substance Registry System: 2-Propenoyl chloride, 3-[4-(acetyloxy)-3-methoxyphenyl]-(50906-12-2)

Safety Data

• Hazardous Substances Data: 50906-12-2(Hazardous Substances Data)

Upstream product

• 1135-24-6 3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 34749-55-8 3-(4-acetoxy-3-methoxyphenyl)prop-2-enoic acid 
• 4046-02-0 ethyl 4-hydroxy-3-methoxycinnamate 
• 331-39-5 caffeic acid 
• 79-37-8 oxalyl dichloride 
• 2596-47-6 (E)-3-(4-acetoxy-3-methoxyphenyl)acrylic acid 
• 881-68-5 vanillin acetate 
• 1135-24-6 (E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid 
• 121-33-5 vanillin 

Downstream Products

• 19856-72-5 2-Methyl-4-(3-methoxy-4-acetoxy-cinnamoyl)-morpholin 
• 19856-73-6 2-Aethyl-4-(3-methoxy-4-acetoxy-cinnamoyl)morpholin 
• 19856-74-7 3-Aethyl-4-(3-methoxy-4-acetoxy-cinnamoyl)morpholin 
• 134896-05-2 (E)-N-(3-hydroxy-1-oxocyclopent-2-en-2-yl)-3-<4-(acetyloxy)-3-methoxyphenyl> propenamide 
• 142886-56-4 methyl 2,3-di-O-acetyl-5-O-(4'-O-acetylferuloyl)-α-L-arabinofuranoside 
• 69017-41-0 (E)-3-(4-acetoxy-3-methoxyphenyl)-2-propen-1-ol 
• 137232-58-7 methyl 4-O-(4-O-acetylferuloyl)-β-D-xylopyranoside 
• 91000-13-4 (2E,2'E)-N,N'-(butane-1,4-diyl)bis(3-(4-hydroxy-3-methoxyphenyl)prop-2-enamide) 
• 95687-10-8 (E)-3-(4-Acetoxy-3-methoxy-phenyl)-acrylic acid 4-nitro-phenyl ester 

Relevant articles and documents

Design of chromogenic probes for efficient screening and evaluation of feruloyl esterase-like activities

Feruloyl esterases (FAEs) constitute an important sub-group of hydrolytic enzymes involved in the deconstruction of plant cell wall polysaccharides. However, in the current era of genomics and metagenomics, finding and characterizing FAEs is not straightf

Stable isotopic labelling of β-sitosteryl ferulate for use as analytical tool

Rice is one of the major staple foods consumed worldwide and due to the presence of γ-oryzanol (γ-OZ) it is well-recognized as functional food. For this reason, the most appropriate varieties' identification in term of content of γ-OZ has become essential

A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects

Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes (T2DM). Ferulic acid is known for attenuating the insulin resistance and reducing the blood glucose in T2DM rats. In this work, we designed and synthesized a library of new ferulic acid amides (FAA), which could be considered as ring opening derivatives of the antidiabetic PPARγ agonists Thiazolidinediones (TZDs). However, since these compounds displayed weak PPAR transactivation capacity, we employed a proteomics approach to unravel their molecular target(s) and identified the peroxiredoxin 1 (PRDX1) as a direct binding target of FAAs. Interestingly, PRDX1, a protein with antioxidant and chaperone activity, has been implied in the development of T2DM by inducing hepatic insulin resistance. SPR, mass spectrometry-based studies, docking experiments and in vitro inhibition assay confirmed that compounds VIe and VIf bound PRDX1 and induced a dose-dependent inhibition. Furthermore, VIe and VIf significantly improved hyperglycemia and hyperlipidemia in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats as confirmed by histopathological examinations. These results provide guidance for developing the current FAAs as new potential antidiabetic agents.