50919-08-9

Basic information

• Product Name: 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE
• Synonyms: TIMTEC-BB SBB009234;ART-CHEM-BB B006175;1-(3,4-DIMETHOXYPHENYL)ETHANAMINE;1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE;AKOS B006175;1-(3,4-dimethoxyphenyl)ethanamine(SALTDATA: HCl);1-(3,4-dimethoxyphenyl)ethanamine 1HCl
• CAS NO: 50919-08-9
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.23
• Mol File: 50919-08-9.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 272°C at 760 mmHg
• Flash Point: 128.2°C
• Appearance: /
• Density: 1.037g/cm³
• Vapor Pressure: 0.00623mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.18±0.10(Predicted)
• CAS DataBase Reference: 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE(50919-08-9)
• EPA Substance Registry System: 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE(50919-08-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 50919-08-9(Hazardous Substances Data)

Usage

General Description

1-(3,4-Dimethoxy-phenyl)-ethylamine, also known as 3,4-Dimethoxyphenethylamine or 3,4-Dimethoxyphenethylamine, is a chemical compound with the molecular formula C10H15NO2. It is a phenethylamine derivative that contains two methoxy groups at the 3 and 4 positions of the phenyl ring. 1-(3,4-DIMETHOXY-PHENYL)-ETHYLAMINE is structurally related to mescaline, a naturally occurring psychedelic alkaloid found in various cactus species. 1-(3,4-Dimethoxy-phenyl)-ethylamine has been studied for its potential psychoactive effects and its similarities to other psychoactive compounds, but its specific pharmacological properties and potential uses are not well-documented. Additionally, its safety, legality, and regulatory status in various jurisdictions are not well-known.

InChI:InChI=1/C10H15NO2/c1-7(11)8-4-5-9(12-2)10(6-8)13-3/h4-7H,11H2,1-3H3

Upstream product

• 2024-83-1 veratronitrile 
• 75-16-1 methylmagnesium bromide 
• 1131-62-0 1-(3,4-dimethoxyphenyl)ethanone 
• 83834-92-8 N-(1-(3,4-dimethoxyphenyl)ethyl)formamide 
• 107146-38-3 1-(3,4-Dimethoxy-phenyl)-ethylamine; compound with sulfuric acid 

Downstream Products

• 65451-89-0 (S)-1-(3',4'-dimethoxyphenyl)ethylamine 
• 1425503-21-4 C₂₂H₂₈N₆O₃ 
• 114754-73-3 1-benzylamino-1-(3,4-dimethoxyphenyl)-ethane 
• 100570-24-9 1-(R)-(3,4-dimethoxyphenyl)ethylamine 
• 180698-56-0 1-Phthalimido-1-(3',4'-dimethoxyphenyl)ethane 
• 6380-23-0 3,4-dimethoxystyrene 
• 523-01-3 (-)-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-ylmethyl)-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinoline 

Relevant articles and documents

Design, synthesis and antifungal activity of threoninamide carbamate derivatives via pharmacophore model

Thirty-six novel threoninamide carbamate derivatives were designed and synthesised using active fragment-based pharmacophore model. Antifungal activities of these compounds were tested against Oomycete fungi Phytophthora capsici in vitro and in vivo. Interestingly, compound I-1, I-2, I-3, I-6 and I-7 exhibited moderate control effect (>50%) against Pseudoperonospora cubensis in greenhouse at 6.25 μg/mL, which is better than that of control. Meanwhile most of these compounds exhibited significant inhibitory against P. capsici. The other nine fungi were also tested. More importantly, some compounds exhibited remarkably high activities against Sclerotinia sclerotiorum, P. piricola and R. solan in vitro with EC50 values of 3.74–9.76 μg/mL. It is possible that the model is reliabile and this method can be used to discover lead compounds for the development of fungicides.

Integrated Heterogeneous Metal/Enzymatic Multiple Relay Catalysis for Eco-Friendly and Asymmetric Synthesis

Organic synthesis is in general performed using stepwise transformations where isolation and purification of key intermediates is often required prior to further reactions. Herein we disclose the concept of integrated heterogeneous metal/enzymatic multiple relay catalysis for eco-friendly and asymmetric synthesis of valuable molecules (e.g., amines and amides) in one-pot using a combination of heterogeneous metal and enzyme catalysts. Here reagents, catalysts, and different conditions can be introduced throughout the one-pot procedure involving multistep catalytic tandem operations. Several novel cocatalytic relay sequences (reductive amination/amidation, aerobic oxidation/reductive amination/amidation, reductive amination/kinetic resolution and reductive amination/dynamic kinetic resolution) were developed. They were next applied to the direct synthesis of various biologically and optically active amines or amides in one-pot from simple aldehydes, ketones, or alcohols, respectively.

Discovery of potent carbonic anhydrase and acetylcholine esterase inhibitors: Novel sulfamoylcarbamates and sulfamides derived from acetophenones

Abstract In this study, several novel sulfamides were synthesized and evaluated for their acetylcholine esterase (AChE) and human carbonic anhydrase I, and II isoenzymes (hCA I and II) inhibition profiles. Reductive amination of methoxyacetophenones was u