50919-63-6Relevant articles and documents
Organocatalyzed Synthesis of Highly Functionalized Phthalimides via Diels-Alder Reaction Employing Two Dienophiles
Akhtar, Muhammad Saeed,Lee, Yong Rok
, p. 15129 - 15138 (2020/12/02)
An efficient and facile protocol for the synthesis of biologically and pharmaceutically important phthalimides is developed by l-proline-catalyzed reaction between two dienophiles of α,β-unsaturated aldehydes and maleimides. The reaction involves an efficient benzannulation that proceeds via a formal [4 + 2] cycloaddition of azadiene intermediates generated in situ from enals and N-substituted maleimides. This protocol provides a variety of functionalized phthalimide derivatives, including a potent COX-2 enzyme inhibitor.
PHTHALIC DIESTER DERIVATIVES AND ELECTRON DONORS
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Example 18, (2008/06/13)
A phthalic acid diester derivative represented by a specific formula and an electron donor used in an olefin polymerization catalyst containing the phthalic acid diester derivative as an effective component. The electron donor can produce polymers with a high stereoregularity at an extremely high polymerization activity and high yield, and exhibit a high response to hydrogen.
Design, Synthesis and Cytotoxicity of 2-Hydroxy-1(H)-isoindole-1,3-dione (HISD) Derivatives Against CEM/O Human Leukemia Cells in vitro
Nandy, Partha,Avramis, Vassilios I.,Lien, Eric J.
, p. 664 - 679 (2007/10/03)
2-Hydroxy-1(H)-isoindole-1,3-dione derivatives (HISDs) possess a hydroxamic acid moiety which is built into an isoindoledione ring. Seven new compounds have been synthesized and tested for cytotoxicity against CEM human leukemia cell lines. Three active c
