5096-21-9

Basic information

• Product Name: N-(2,4,6-Trimethylphenyl)acetamide
• Synonyms: Acetomesidide;N-(2,4,6-Trimethylphenyl)acetamide;N-mesitylacetamide
• CAS NO: 5096-21-9
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.27
• Mol File: 5096-21-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 216.5°C
• Boiling Point: 309.18°C (rough estimate)
• Flash Point: 170.1°C
• Appearance: /
• Density: 1.0290 (rough estimate)
• Vapor Pressure: 0.00197mmHg at 25°C
• Refractive Index: 1.5480 (estimate)
• CAS DataBase Reference: N-(2,4,6-Trimethylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,4,6-Trimethylphenyl)acetamide(5096-21-9)
• EPA Substance Registry System: N-(2,4,6-Trimethylphenyl)acetamide(5096-21-9)

Safety Data

• Hazardous Substances Data: 5096-21-9(Hazardous Substances Data)

Usage

General Description

N-(2,4,6-Trimethylphenyl)acetamide, also known as acetaminomal, is a chemical compound that is commonly used as an analgesic and antipyretic medication. It is an amide and a derivative of acetaminophen, a widely used over-the-counter pain reliever and fever reducer. The chemical is structurally similar to acetaminophen, with the addition of a functional group that contains a nitrogen atom bonded to a carbonyl group, which gives it its amide classification. N-(2,4,6-Trimethylphenyl)acetamide works by inhibiting the production of prostaglandins, which are associated with pain and fever, in the brain and spinal cord. Its analgesic and antipyretic properties make it a popular choice for treating mild to moderate pain, such as headaches, muscle aches, and toothaches, as well as reducing fever. However, it is important to use this chemical with caution, as high doses or prolonged use can lead to liver damage.

InChI:InChI=1/C11H15NO/c1-7-5-8(2)11(9(3)6-7)12-10(4)13/h5-6H,1-4H3,(H,12,13)

Upstream product

• 108-24-7 acetic anhydride 
• 88-05-1 2,4,6-trimethylaniline 
• 60-35-5 acetamide 
• 98-04-4 phenyltrimethylammonium iodide 
• 75-05-8 acetonitrile 
• 527-60-6 Mesitol 
• 125261-32-7 2,4,6-trimethylphenyl trifluoromethanesulfonate 
• 106-49-0 p-toluidine 
• 2050-43-3 N-(2,4-dimethylphenyl)acetamide 
• 112359-25-8 5-(trifluoromethyl)dibenzothiophenium trifluoromethanesulfonate 
• 103-89-9 4-Methylacetanilide 
• 64-19-7 acetic acid 
• 46005-00-9 Ethylidyne-(2,4,6-trimethyl-phenyl)-ammonium 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 23592-67-8 N-mesitylaniline 
• 79825-75-5 N-methyl-2,4,6-trimethyldiphenylamine 
• 489-96-3 2-amino-1,3,5-benzenetricarboxylic acid 
• 1148021-53-7 1-N-(4'-cyanophenyl)-2,4-dinitro-N-acetoxy-5-N-[(2',4',6'-trimethylphenyl)]benzene-1,5-diamine 
• 40752-00-9 N-mesityl-N-methylacetamide 

Relevant articles and documents

On the Beckmann Rearrangement of Ketoximes: A Kinetic Study in Trifluoromethanesulfonic Acid

The formation and the destruction of an intermediate involved in the Beckmann rearrangement of 2,4,6-trimethylacetophenone oxime have been studied in concentrated trifluoromethanesulfonic acid by kinetic and spectroscopic measurements. Observed (kobs

New half-sandwich (η6-p-cymene)ruthenium(II) complexes with benzothiazole hydrazone Schiff base ligand: Synthesis, structural characterization and catalysis in transamidation of carboxamide with primary amines

Few half-sandwich (η6-p-cymene) ruthenium(II) complexes supported by benzothiazole hydrazone Schiff bases were synthesized. The new complexes possess the general formulae [Ru(η6-p-cymene)(L)Cl] (1-3) (L = salicyl((2-(benzothiazol-2-yl)hydrazono)methylphenol) (SAL-HBT), 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) (VAN-HBT) or naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol) (NAP-HBT). All compounds were fully studied by analytical, spectroscopic techniques (IR, NMR) and also by mass spectrometry. The solid state structure of the complex 3 reveals the coordination of p-cymene moieties with ruthenium(II) in a three-legged piano-stool geometry along with benzothiazole hydrazone Schiff base ligand in a monobasic bidentate fashion. The catalytic properties of the complexes were screened in transamidation of primary amide with amines after optimization with respect to solvent, substituents, time and catalyst loading. The results show that the complex 3 is the most efficient catalyst for the transamidation of carboxamides with amines.

Diaryl-λ3-chloranes: Versatile Synthesis and Unique Reactivity as Aryl Cation Equivalent

We have developed a versatile, high-yield synthesis of diarylchloroniums/λ3-chloranes through the reaction of various chloroarenes with readily prepared mesityldiazonium tetrakis(pentafluorophenyl)borate under mild conditions. The scope of the reaction is broad, including ArCl, ArBr, and ArI. The diarylchloroniums/λ3-chloranes prepared here show unique reactivity in various respects, enabling intermolecular electrophilic arylation reaction of weak nucleophiles, and chlorane-halogane exchange reaction.