50991-85-0

Basic information

• Product Name: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trimethoxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
• Synonyms: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trimethoxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
• CAS NO: 50991-85-0
• Molecular Weight: 750.794
• Mol File: 50991-85-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trimethoxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trimethoxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one(50991-85-0)
• EPA Substance Registry System: 2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trimethoxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one(50991-85-0)

Safety Data

• Hazardous Substances Data: 50991-85-0(Hazardous Substances Data)

Upstream product

• 153-18-4 rutin 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Relevant articles and documents

Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells

Three methylated quercetins and a series of O-3 substituted 5,7,3′,4′-tetra-O-methylated quercetin derivatives have been synthesized and evaluated on the modulating activity of P-gp, BCRP and MRP1 in cancer cell lines. Compound 17 (with a 2-((4-methoxybenzoyl)oxy)ethyl at O-3) is the most potent P-gp modulator. Three derivatives, compound 9 (3,7,3′,4′-tetra-O-methylated quercetin), compound 14 (with a 2-((3-oxo-3-(3,4,5trimethoxyphenyl)prop-1-en-1-yl)oxy)ethyl at O-3) and compound 17, consistently exhibited promising BCRP-modulating activity. Interestingly, compound 17 was found to be equipotent against both P-gp and BCRP. Importantly, these synthetic quercetin derivatives did not exhibit any inherent cytotoxicity to cancer cell lines or normal mouse fibroblast cell lines. These quercetin derivatives can be employed as safe and effective modulators of P-gp- or BCRP-mediated drug resistance in cancer.