5100-21-0

Basic information

• Product Name: ethyl 4-[(ethoxycarbonyl)amino]benzoate
• Synonyms: benzoic acid, 4-[(ethoxycarbonyl)amino]-, ethyl ester; Ethyl 4-[(ethoxycarbonyl)amino]benzoate
• CAS NO: 5100-21-0
• Molecular Formula: C₁₂H₁₅NO₄
• Molecular Weight: 237.2518
• Mol File: 5100-21-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 309.4°C at 760 mmHg
• Flash Point: 140.9°C
• Density: 1.187g/cm³
• Vapor Pressure: 0.000642mmHg at 25°C
• Refractive Index: 1.546
• CAS DataBase Reference: ethyl 4-[(ethoxycarbonyl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-[(ethoxycarbonyl)amino]benzoate(5100-21-0)
• EPA Substance Registry System: ethyl 4-[(ethoxycarbonyl)amino]benzoate(5100-21-0)

Safety Data

• Hazardous Substances Data: 5100-21-0(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 3729-21-3 4-isocyanatobenzoic acid chloride 
• 91133-79-8 S-Methyl-N-<4-ethoxycarbonyl-phenyl>-thiolcarbamat 
• 590-28-3 potassium cyanate 
• 7335-27-5 ethyl 4-chlorobenzoate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 62-23-7 4-nitro-benzoic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 94-09-7 p-aminoethylbenzoate 
• 5798-75-4 Ethyl 4-bromobenzoate 
• 51-79-6 urethane 
• 22669-27-8 p-aminobenzoic acid hydrochloride 
• 15030-72-5 Z-Aib-OH 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 57834-33-0 N-(4-ethoxycarbonylphenyl)-N'-methyl-N'-phenylformamidine 
• 23598-65-4 4-(2-oxo-5-prop-2-ynyloxymethyl-oxazolidin-3-yl)-benzoic acid ethyl ester 

Relevant articles and documents

Synthesis of N-(Hetero)aryl Carbamates via CuI/MNAO Catalyzed Cross-Coupling of (Hetero)aryl Halides with Potassium Cyanate in Alcohols

An efficient route to N-(hetero)aryl carbamates was developed through CuI/MNAO [2-((2-methylnaphthalen-1-yl)amino)-2-oxoacetic acid] catalyzed cross-coupling of (hetero)aryl chlorides with potassium cyanate in alcohols at 120-130 °C. This method utilizes

Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis

A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.