51022-74-3 Usage
Originator
Biliscopin,Schering,W. Germany,1978
Uses
Diagnostic aid (radiopaque medium).
Manufacturing Process
(a) Condensation in dimethylacetamide: To a suspension of 51.5 g of
anhydrous 3-amino-2,4,6-triiodo-benzoic acid (0.1 mol) in 100 ml of
dimethylacetamide were slowly added dropwise, while stirring, 15.5 g of
3,6,9-trioxaundecanediacid dichloride (0.06 mol), during which the
temperature gradually rose to about 50°C and the whole passed into solution.
After being stirred overnight, the solution was added dropwise to 1 liter of a
0.28 N solution of sodium hydroxide, and then 200 ml of 2 N hydrochloric acid
were cautiously added. The precipitate was filtered off with suction, washed
with water and dried. The yield was practically quantitative.(b) Condensation in dioxan: 15.5 g of 3,6,9-trioxaundecane diacid dichloride
were added dropwise at about 95°C to a solution of 51.5 g of anhydrous 3-
amino-2,4,6-triiodo-benzoic acid in 52 ml of anhydrous dioxan. After further
stirring and heating for 3 hours, the solution was cooled, stirred dropwise into
500 ml of a 0.4 N solution of sodium hydroxide, and further worked up as
described in paragraph (a). The yield was practically quantitative.(c) Purification: To the crude product obtained as described under paragraph
(a) or (b) in 300 ml of methanol was slowly added a quantity (about 15 ml) of
a 12 N solution of sodium hydroxide such that a test portion diluted with
water had a pH-value of 8 to 9. After stirring the mixture overnight, the
sodium salt of 3,6,9-trioxaundecane-1,11-dioyl-bis-(3-carboxy-2,4,6-triodoanilide) which crystallized out was filtered off with suction, was hed with
methanol and dried. Yield: 92 g (90% of the theoretical yield).A solution of the salt in 900 ml of water was treated with active carbon, and
concentrated hydrochloric acid was added until the pH-value was 1. The
precipitate was filtered off with suction, washed with water, and dried at 50°C.The yield of pure 3,6,9-trioxaundecane-1,11-dioyl-bis-(3-carboxy-2,4,6-
triiodo-anilide) was 80 g (80% of the theoretical yield). The substance melted
at 175°C with sintering.
Therapeutic Function
Diagnostic aid (radiopaque medium)
Flammability and Explosibility
Notclassified
Check Digit Verification of cas no
The CAS Registry Mumber 51022-74-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,2 and 2 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 51022-74:
(7*5)+(6*1)+(5*0)+(4*2)+(3*2)+(2*7)+(1*4)=73
73 % 10 = 3
So 51022-74-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H18I6N2O9/c23-9-5-11(25)19(17(27)15(9)21(33)34)29-13(31)7-38-3-1-37-2-4-39-8-14(32)30-20-12(26)6-10(24)16(18(20)28)22(35)36/h5-6H,1-4,7-8H2,(H,29,31)(H,30,32)(H,33,34)(H,35,36)
