51047-56-4

Basic information

• Product Name: 1-(6-Pyridazinyl)piperazine
• Synonyms: 1-(6-Pyridazinyl)piperazine;3-Piperazin-1-yl-pyridazine;Pyridazine, 3-(1-piperazinyl)-
• CAS NO: 51047-56-4
• Molecular Formula: C₈H₁₂N₄
• Molecular Weight: 164.21
• Mol File: 51047-56-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 381.075oC at 760 mmHg
• Flash Point: 184.268oC
• Appearance: /
• Density: 1.139g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.60±0.10(Predicted)
• CAS DataBase Reference: 1-(6-Pyridazinyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-Pyridazinyl)piperazine(51047-56-4)
• EPA Substance Registry System: 1-(6-Pyridazinyl)piperazine(51047-56-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51047-56-4(Hazardous Substances Data)

Usage

General Description

1-(6-Pyridazinyl)piperazine is a chemical compound that typically takes the form of a powder or crystalline solid and is often utilized in various scientific research studies. As an organic compound, it belongs to the class of chemical entities known as piperazines and features a piperazine ring system. However, its exact usage, properties, and effects can vary based on the context of its application. It's vital to carefully handle and store this chemical in a dry, cool, and ventilated area due to its reactivity nature. It's also important to note that safety precautions, including wearing appropriate protective equipment and following safe laboratory practices, should be adhered to when handling this chemical.

InChI:InChI=1/C8H12N4/c1-2-8(11-10-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2

Upstream product

• 362661-27-6 1-(6'-chloro-2'-pyridazinyl)-4-benzylpiperazine 
• 56392-83-7 3-chloro-6-piperazin-1-yl-pyridazine 
• 492431-12-6 tert-butyl 4-(pyridazin-3-yl)piperazine-1-carboxylate 

Relevant articles and documents

PHENYL mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Structure-affinity relationships of a unique nicotinic ligand: N1-dimethyl-N4-phenylpiperazinium iodide (DMPP)

DMPP is a well-known nicotinic agonist that does not fit any proposed pharmacophore for nicotinic binding and represents a unique ligand among the hundreds of nicotinic agonists studied in the past decades. A systematic modulation of the chemical structure of DMPP, aimed to establish its structure-affinity relationships, is reported. The research has allowed to identify molecules such as 11c, 13c, 14c, and 28c, with affinities for α4β2 receptors in the low nanomolar range, some 2 orders of magnitude lower than the lead compound. The agonistic properties of the most interesting compounds have been assessed by measuring their analgesic activity on mice (hot-plate test). Another result of the research was the identification of DMPP analogues, such as 3a (Ki = 90 nM) and 14b (Ki = 180 nM), that maintain affinity for the central nicotinic receptor when the ammonium function is changed into an aminic one and are therefore possible leads for drug development in neurodegenerative diseases.