51077-50-0

Basic information

• Product Name: 7,8-DIHYDRORETINOICACID
• Synonyms: 7,8-DIHYDRORETINOICACID;(2E,4E,6E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6-nonatrienoic acid;(2E,4E,6E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6-nonatrienoic acid;Ro-11-0874
• CAS NO: 51077-50-0
• Molecular Formula: C20H30O2
• Molecular Weight: 302.50
• Mol File: 51077-50-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 383.47°C (rough estimate)
• Flash Point: 335.7°C
• Appearance: /
• Density: 1.0434 (rough estimate)
• Vapor Pressure: 3.62E-09mmHg at 25°C
• Refractive Index: 1.4980 (estimate)
• CAS DataBase Reference: 7,8-DIHYDRORETINOICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 7,8-DIHYDRORETINOICACID(51077-50-0)
• EPA Substance Registry System: 7,8-DIHYDRORETINOICACID(51077-50-0)

Safety Data

• Hazardous Substances Data: 51077-50-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H30O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14,17-18H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14-

Upstream product

• 28290-33-7 (E)-3-methyl-5-(2',6',6'-trimethylcyclohex-1'-en-1'-yl)pent-2-enal 
• 19945-48-3 Methyl 4-(diethyl phosphono)-3-methyl-2-butenoate 
• 19945-56-3 methyl 4-diethylphosphono-3-methyl-2-butenoate 

Relevant articles and documents

Dihydroretinoic acids and their derivatives. Synthesis and biological activity

The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds was evaluated in vivo in a chemically induced mouse skin papilloma test and in vitro in two vitamin A deficient assays. The activity observed for 1a, 1c, and 2a in the former test was partially retained in the dihydro derivatives 4b, 4c, and 6b. Similar results were found in the in vitro assays.