5108-51-0 Usage
Description
1-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)methanamine, commonly known as riluzole, is a pharmaceutical compound belonging to the benzothiadiazine class. It is characterized by its ability to modulate neurotransmitter levels in the brain, specifically by regulating glutamate, which plays a crucial role in the treatment of certain neurological conditions.
Uses
Used in Pharmaceutical Industry:
1-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)methanamine is used as a therapeutic agent for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Its application is based on its ability to regulate the levels of the neurotransmitter glutamate in the brain, which helps slow down the progression of ALS.
Additionally, riluzole has shown potential in the treatment of other neurological conditions such as depression, bipolar disorder, and neuropathic pain. This is due to its modulatory effects on neurotransmitter levels, which can influence various aspects of brain function and mood regulation.
Furthermore, riluzole has been the subject of numerous research studies and clinical trials, indicating its potential for expanded therapeutic applications in the future. As our understanding of its mechanisms of action and efficacy in different conditions grows, riluzole may become an increasingly important compound in the treatment of a range of neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 5108-51-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,0 and 8 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 5108-51:
(6*5)+(5*1)+(4*0)+(3*8)+(2*5)+(1*1)=70
70 % 10 = 0
So 5108-51-0 is a valid CAS Registry Number.
5108-51-0Relevant articles and documents
4-Hydroxy-2-quinolones. 47. Synthesis and diuretic activity of (2H-1,2,4,benzothiadiazine-1,1-dioxide-3-yl)methylamides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids
Taran,Ukrainets,Likhanova,Gorokhova,Bezugly
, p. 237 - 240 (2007/10/03)
With the aim of investigating the relationship between chemical structure and biological activity we have synthesized and studied the effect of (2H-1,2,4-benzothiadiazine-1,1-dioxide-3-yl)methylamides of 1-R-4-hydroxy-2-oxoquinoline-3-carboxylic acids on kidney urinary output.
