51091-84-0

Basic information

• Product Name: (S)-(+)-Naproxen chloride
• Synonyms: (S)-(+)-Naproxen chloride;(S)-2-(6-Methoxynaphthalen-2-yl)propanoyl chloride;(S)-(+)-Naproxen chloride >=97.0%
• CAS NO: 51091-84-0
• Molecular Formula: C₁₄H₁₃ClO₂
• Molecular Weight: 301.16516
• Mol File: 51091-84-0.mol
• Article Data: 69

Chemical Properties

• Melting Point: 94-96 °C
• Boiling Point: 371.6°Cat760mmHg
• Flash Point: 136.9°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 1.02E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-(+)-Naproxen chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-Naproxen chloride(51091-84-0)
• EPA Substance Registry System: (S)-(+)-Naproxen chloride(51091-84-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36-52
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 51091-84-0(Hazardous Substances Data)

Usage

Description

(S)-(+)-Naproxen chloride, a nonsteroidal anti-inflammatory drug (NSAID), is utilized to alleviate pain, inflammation, and fever. It operates by inhibiting the production of natural substances in the body that trigger inflammation. As the active form of naproxen, (S)-(+)-Naproxen chloride is recognized for its higher potency. It is widely employed to mitigate the symptoms of various conditions, including arthritis, menstrual cramps, tendonitis, and bursitis. While generally safe when used as prescribed, it may cause side effects such as stomach upset, diarrhea, and dizziness. Caution is advised for individuals with a history of stomach ulcers, kidney issues, or heart disease.

Uses

Used in Pharmaceutical Industry:
(S)-(+)-Naproxen chloride is used as an anti-inflammatory agent for its ability to reduce pain and inflammation. It is particularly effective in treating conditions like arthritis, menstrual cramps, tendonitis, and bursitis due to its potent action in blocking the production of inflammatory substances in the body.
Used in Pain Management:
(S)-(+)-Naproxen chloride is used as an analgesic for managing mild to moderate pain. Its effectiveness in reducing pain and inflammation makes it a suitable choice for various painful conditions.
Used in Treatment of Fever:
(S)-(+)-Naproxen chloride is used as an antipyretic to lower fever. Its ability to reduce the body's production of prostaglandins, which are involved in fever, makes it a useful medication for this purpose.
Used in Patient Care:
(S)-(+)-Naproxen chloride is used as a therapeutic agent for improving the quality of life of patients suffering from painful and inflammatory conditions. Its use can help patients lead more comfortable and active lives by reducing their symptoms.

InChI:InChI=1/C14H13ClO2/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3/t9-/m0/s1

Upstream product

• 26159-34-2 Naprelan 
• 7719-09-7 thionyl chloride 
• 22204-53-1 (2S)-2-(6-methoxy(2-naphthyl))propanoic acid 
• 79-37-8 oxalyl dichloride 
• 32305-59-2 S-2-(6-methoxy-2-naphthyl)propionaldehyde 
• 22204-53-1 (+)-2-(6-methoxy-2-naphthyl)propionic acid 

Downstream Products

• 136404-15-4 4-[2-(6-methoxy-2-naphthyl)propionamido]phenol 
• 908243-78-7 2-methoxy-4-methylphenyl (S,S)-1-(2-(6-methoxynaphthalen-2-yl)propanoyl)pyrrolidine-2-carboxylate 
• 84236-26-0 S-(+)-2-(5-Bromo-6-Methoxy-2-Naphthyl)-Propionic Acid 

Relevant articles and documents

Non-carboxylic Analogues of Aryl Propionic Acid: Synthesis, Anti-inflammatory, Analgesic, Antipyretic and Ulcerogenic Potential

As a part of ongoing studies in developing new potent anti-inflammatory and analgesic agents, a series of novel 6-methoxy naphthalene derivatives was efficiently synthesized and characterized by spectral and elemental analyses. The newly synthesized compounds were evaluated for their anti-inflammatory activities using carrageenin-induced rat paw edema model, analgesic activities using acetic acid induced writhing model in mice and anti-pyretic activity using yeast induced hyperpyrexia method as well as ulcerogenic effects. Among the synthesized compounds, thiourea derivative (6a, e) exhibited higher anti-inflammatory activity than the standard drug naproxen in reduction of the rat paw edema (88.71, 89.77%) respectively. All of the non-carboxylic tested compounds were found to have promising anti-inflammatory, analgesic and antipyretic activity, while were devoid of any ulcerogenic effects.

Chiral lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reactions of nitrogen-stabilized oxyallyl cations derived from allenamides

A chiral Lewis acid-catalyzed highly enantioselective [4 + 3] cycloaddition reaction of allenamide-derived nitrogen-stabilized chiral oxyallyl cations is described here. The use of bisoxazoline ligand and CuOTf2 provides high enantioselectivity, especially with [SbF6]- as the counteranion. Copyright

S-(+)-naproxen chloride as acylating agent for separating the enantiomers of chiral amines and alcohols

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Esterase-activated release of naproxen from supramolecular nanofibres

Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained. This journal is

Practical and sustainable approach for clean preparation of 5-organylselanyl uracils

An eco-friendly, sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and diorganyl diselenides at room temperature under oxidant- and external electrolyte-free cond

Visible-Light-Induced Radical Defluoroborylation of Trifluoromethyl Alkenes: An Access to gem-Difluoroallylboranes

A photoredox-catalyzed defluoroborylation of trifluoromethyl alkenes with N-heterocyclic carbene boranes is described for the synthesis of gem-difluoroallylboranes. This protocol exhibits a broad substrate scope and good functional group compatibility, which enables the late-stage functionalization of structurally complex compounds. Further transformations of the defluoroborylation products to valuable CF2-containing molecules are also demonstrated. (Figure presented.).