5117-56-6Relevant articles and documents
A Copper Halide Promoted Regioselective Halogenation of Coumarins Using N-Halosuccinimide as Halide Source
Su, Jinling,Zhang, Yan,Chen, Mingren,Li, Weiming,Qin, Xuewei,Xie, Yanping,Qin, Lixiao,Huang, Shihua,Zhang, Min
supporting information, p. 630 - 634 (2019/03/08)
A safe, convenient, and regioselective synthesis of 3-halo coumarins using a metal halide (CuX 2 alone or with ZnX 2) promoted halogenation with N -halosuccinimide (NXS) as halide source is reported. The synthesis involved the steady in situ generation of highly reactive positive halogen (X +) by the coordination of copper or zinc with the N -halosuccinimide and subsequent electrophilic aromatic substitution of the electron-deficient coumarins. This procedure works well also for the halogenation of less electron-rich naphthoquinones, flavones, and methoxypsoralen in moderate to quantitative yields. This protocol features simple experimental conditions using readily available inexpensive reagents and provides a convenient approach to the chlorination or bromination of some useful heteroaromatic compounds.
A novel 3-chloro-coumarin derivatives preparation method (by machine translation)
-
Paragraph 0035; 0036; 0037; 0038; 0039; 0040; 0041-0044, (2016/10/10)
The invention discloses a novel 3-chloro-coumarin derivatives of the preparation method, comprising the following operations: the coumarin derivatives as a chlorine source of the N-chloro succinimide (NCS) mixed, dissolved in an organic solvent, in the presence of salt catalyst, 82-200 °C reflux reaction 8-45h preparation of 3-chloro-coumarin derivatives. The method of the invention for preparing the resulting 3-chloro-coumarin derivatives, the ace can reach its yield is 95.5%, note the method of the invention has very good regioselectivity. And the method of the invention the raw material is easy to obtain, reaction is easy to control, after-treatment is simple and convenient the low characteristic of toxicity. (by machine translation)