51170-55-9

Basic information

• Product Name: tert-Butyl isopropylcarbaMate
• Synonyms: tert-Butyl isopropylcarbaMate;Tert-Butyl N-(Propan-2-Yl)Carbamate
• CAS NO: 51170-55-9
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.22608
• Mol File: 51170-55-9.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly, Heated), Chloroform (Slightly), DMSO (Slightly, Heated)
• CAS DataBase Reference: tert-Butyl isopropylcarbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl isopropylcarbaMate(51170-55-9)
• EPA Substance Registry System: tert-Butyl isopropylcarbaMate(51170-55-9)

Safety Data

• Hazardous Substances Data: 51170-55-9(Hazardous Substances Data)

Usage

Description

tert-Butyl isopropylcarbamate, also known as tert-Butyl N-(Propan-2-yl)carbamate, is an organic compound that serves as an intermediate in the synthesis of various organic compounds.
Used in Pharmaceutical Industry:
tert-Butyl isopropylcarbamate is used as an intermediate in the synthesis of N-Ethyl-N-nitroso-2-propanamine (E932795) for the production of Amino Acids, Peptides, and Proteins. This intermediate plays a crucial role in the development of pharmaceutical compounds and contributes to the advancement of drug discovery and synthesis processes.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 75-31-0 isopropylamine 
• 183311-28-6 (3-Amino-pyridin-4-yl)-carbamic acid tert-butyl ester 
• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 1310366-25-6 [(tert-butoxy)carbonyl]amino 2-methylpropanoate 
• 1370046-86-8 C₁₈H₃₉N₃O₅Si 
• 1370046-89-1 C₁₄H₁₉N₅O₈ 
• 1370046-88-0 C₁₁H₂₁N₃O₆ 
• 267668-32-6 N-tert-butyloxycarbonyl-N-(1,1,2-trimethyl-2-propenyl)benzenesulfenamide 
• 78-84-2 isobutyraldehyde 
• 108655-58-9 3-(t-butoxycarbonyl)-3H-v-triazolo<4,5-b>pyridine 
• 108655-53-4 1-t-butoxycarbonyl-v-triazolo<4,5-b>pyridine 
• 75-65-0 tert-butyl alcohol 
• 1795-48-8 Isopropyl isocyanate 

Downstream Products

• 1001270-64-9 tert-butyl ((S)-2-(4-chlorophenyl)-3-(4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazin-1-yl)-3-oxopropyl)(isopropyl)carbamate 
• 1001179-33-4 (S)-3-((tert-butoxycarbonyl)(isopropyl)amino)-2-(4-chlorophenyl)propionic acid 
• 1396256-89-5 tert-butyl (S)-(3-((R)-4-benzyl-2-oxooxazolidin-3-yl)-2-(4-chlorophenyl)-3-oxopropyl)isopropylcarbamate 
• 1396517-94-4 tert-butyl isopropyl(4-methoxybenzyl)carbamate 
• 913963-65-2 1,1-dimethylethyl {2-{{(1S)-1-[(diphenylphosphino)methyl]-2-methylpropyl}amino}ethyl}(1-methylethyl)carbamate 
• 844851-97-4 1,1-dimethylethyl (1-methylethyl)(2-oxoethyl)carbamate 

Relevant articles and documents

ARYL SULFONAMIDES AS SMALL MOLECULE STAT3 INHIBITORS

The present disclosure provides pharmaceutical compositions comprising aryl sulfonamide Stat3 small molecule inhibitors and certain pharmaceutically acceptable salts thereof, and methods of their use for treating cancer.

Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.

Synthesis of Akt inhibitor ipatasertib. part 2. Total synthesis and first kilogram scale-up

Herein, the first-generation process to manufacture Akt inhibitor Ipatasertib through a late-stage convergent coupling of two challenging chiral components on multikilogram scale is described. The first of the two key components is a trans-substituted cyc