51219-55-7

Basic information

• Product Name: 3-{[(benzyloxy)carbonyl]aMino}-3-Methylbutanoic acid
• Synonyms: 3-{[(benzyloxy)carbonyl]aMino}-3-Methylbutanoic acid;N-Cbz-3-amino-3-methylbutanoic acid
• CAS NO: 51219-55-7
• Molecular Formula: C₁₃H₁₇NO₄
• Molecular Weight: 251.27838
• Mol File: 51219-55-7.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-{[(benzyloxy)carbonyl]aMino}-3-Methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-{[(benzyloxy)carbonyl]aMino}-3-Methylbutanoic acid(51219-55-7)
• EPA Substance Registry System: 3-{[(benzyloxy)carbonyl]aMino}-3-Methylbutanoic acid(51219-55-7)

Safety Data

• Hazardous Substances Data: 51219-55-7(Hazardous Substances Data)

Usage

General Description

3-{[(Benzyloxy)carbonyl]amino}-3-methylbutanoic acid is a complex organic compound that consists of a 3-Methylbutanoic acid backbone. It has been functionalized at one end of the compound with an amino group and protected by a benzyloxycarbonyl (Z) group. The benzyloxycarbonyl group is often used in organic chemistry and biochemistry to protect an amino group during the synthesis of peptide chains. However, the specific properties, uses, or role of this exact chemical compound may not be widely documented and it could be used in research or as a specific reactant for complex organic synthesis.

Upstream product

• 597-43-3 2,2-dimethylsuccinic acid 
• 54043-71-9 4-methoxy-2,2-dimethyl-4-oxobutanoic acid 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 625-05-8 3-amino-3-methylbutanoic acid 
• 100-51-6 benzyl alcohol 
• 541-47-9 3-Methylbutenoic acid 
• 6300-94-3 5,6-dihydro-6,6-dimethyluracil 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 128182-82-1 3-[Benzyloxycarbonylamino]-3-methylbutanoic acid,methyl ester 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 914939-77-8 3-methyl-3-(methyl{[(phenylmethyl)oxy]carbonyl}amino)butanoic acid 
• 1037832-97-5 2-(acetylthio)ethyl 3-(benzyloxycarbonylamino)-3-methylbutanoate 
• 1037832-98-6 2-(3-(benzyloxycarbonylamino)-3-methylbutanoyloxy)ethanesulfonic acid 
• 1322065-45-1 benzyl 4,6-dihydroxy-2-methylhexan-2-ylcarbamate 
• 1163298-06-3 C₁₃H₁₈N₂O₃ 
• 1080675-03-1 (2-dimethylcarbamoyl-1,1-dimethylethyl)-carbamic acid benzyl ester 
• 956473-00-0 3-benzyloxycarbonylamino-3-methylbutaneperoxoic acid 1-methoxy-1-methylethyl ester 
• 145457-70-1 3-benzyloxycarbonylamino-3-methyl-N[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]butanamide 
• 145554-02-5 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide 
• 114359-54-5 (S)-2-(3-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionic acid 
• 164864-45-3 (S)-2-(3-Amino-3-methyl-butyrylamino)-3-phenyl-propionic acid 
• 162356-94-7 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3(R)-yl]-butanamide 

Relevant articles and documents

Trimethyl-substituted carbamate as a versatile self-immolative linker for fluorescence detection of enzyme reactions

Self-immolative linker is a useful building block of molecular probes, with broad applications in the fields of enzyme activity analysis, stimuli-responsive material science, and drug delivery. This manuscript presents N-methyl dimethyl methyl (i.e., trimethyl) carbamate as a new class of self-immolative linker for the fluorescence detection of enzyme reactions. The trimethyl carbamate was shown to spontaneously undergo intramolecular cyclization upon formation of a carboxylate group, to liberate a fluorophore with the second time rapid reaction kinetics. Interestingly, the auto-cleavage reaction of trimethyl carbamate was also induced by the formation of hydroxyl and amino groups. Fluorescent probes with a trimethyl carbamate could be applicable for fluorescence monitoring of the enzyme reactions catalyzed by esterase, ketoreductase, and aminotransferase, and for fluorescence imaging of intracellular esterase activity in living cells, hence demonstrating the utility of this new class of self-immolative linker.

N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents

2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt (2a), a stable derivative of endogenous N,N-dichlorotaurine (1), has been identified and is under development as a topical antimicrobial agent. Structure-activity relationships of analogs were explored to achieve optimal antimicrobial activity with minimal mammalian toxicity while maintaining the desired stability. All the analogs synthesized showed antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans in the range of 1-128 μg/mL and cytotoxicity against mammalian L929 cells in the range 80-1900 μg/mL.

N-HALOGENATED AMINO COMPOUNDS AND DERIVATIVES

The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.