51219-89-7

Basic information

• Product Name: TETRAMETHYLUREA-D12
• Synonyms: TETRAMETHYLUREA-D12;TETRAMETHYL-D12-UREA;tetra[(2H3)methyl]urea;Tetramethylurea-d;N,N,N'',N''-Tetramethyl-d12 urea;TETRAMETHYLUREA-D12, 99+ ATOM % D, FOR NMR;1,1,3,3-Tetra(2H3)methylurea;N,N,N',N'-Tetra(2H3)methylurea
• CAS NO: 51219-89-7
• Molecular Formula: C5D12N2O
• Molecular Weight: 128.24
• EINECS: 257-062-9
• Mol File: 51219-89-7.mol
• Article Data: 83

Chemical Properties

• Melting Point: 1 °C
• Boiling Point: 174-178 °C
• Flash Point: 65 °C
• Appearance: clear colorless liquid
• Density: 0.946 g/cm³
• Vapor Pressure: 1.16mmHg at 25°C
• Refractive Index: 1.445
• CAS DataBase Reference: TETRAMETHYLUREA-D12(CAS DataBase Reference)
• NIST Chemistry Reference: TETRAMETHYLUREA-D12(51219-89-7)
• EPA Substance Registry System: TETRAMETHYLUREA-D12(51219-89-7)

Safety Data

• Hazard Codes: T
• Statements: 61
• Safety Statements: 53-45
• Hazardous Substances Data: 51219-89-7(Hazardous Substances Data)

Usage

Description

TETRAMETHYLUREA-D12, also known as Tetramethyl-d12-urea, is an isotopically labeled research compound with the CAS number 51219-89-7. It is a clear colorless liquid that is primarily used in various scientific research applications due to its unique properties.

Uses

Used in Research Applications:
TETRAMETHYLUREA-D12 is used as a research compound for [application reason] in the field of [application industry]. Its isotopically labeled nature allows for enhanced tracking and analysis in various experimental setups, making it a valuable tool for researchers.
Since the provided materials do not specify the exact application reasons and industries for TETRAMETHYLUREA-D12, it is not possible to list them separately as done for Gallotannin. However, the general use as a research compound is mentioned above. If more specific information about its applications is provided, a more detailed breakdown can be given.

InChI:InChI=1/C5H12N2O/c1-6(2)5(8)7(3)4/h1-4H3

Upstream product

• 865-50-9 iodomethane-d3 
• 57-13-6 urea 
• 91-63-4 2-methylquinoline 
• 1780-17-2 quinolin-2-ylmethanol 
• 81124-50-7 (E)-3-(2-quinolinyl)-2-propenoic acid 
• 123-75-1 pyrrolidine 
• 76253-74-2 2-(chloromethyl)quinoline N-oxide 
• 110-89-4 piperidine 
• 110-88-3 1,3,5-Trioxan 
• 91-22-5 quinoline 
• 4377-41-7 2-Chloromethylquinoline 
• 79-46-9 2-nitropropane 
• 53867-81-5 2-(dibromomethyl)quinoline 
• 67-56-1 methanol 

Relevant articles and documents

Oxidative sp3 C–H Functionalization of Methyl Substituted Aza-Aromatics: An Easy Access to N-Fused Polyheterocycles

An efficient metal-free, one-pot strategy has been developed for the synthesis of diverse N-fused polyheterocycles such as pyrido-/thiazolo-/benzthiazolo-imidazo[4,5-c]quinolines and indolo-/pyrrolo-[1,2-a]quinoxalines mediated by I2/DMSO in the presence of 10 mol-% TBHP. This protocol involves a cascade sequence of oxidative imination/cyclization/aromatization reactions through sp3 C–H functionalization of methyl-substituted aza-aromatics with a variety of arylamine conjugated heterocycles by means of modified Pictet–Spengler type cyclization. The advantage of the present method includes environmentally benign, atom economy, and mild reaction conditions resulting in various N-fused polyheterocycles.

Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum

Visualization of the structure of the Endoplasmic Reticulum (ER) in living cells is important for the understanding of its function. Here we synthesized a library of 8 BODIPY labeledhydroxyquinoline derivatives and evaluated their spectroscopic properties, cytotoxicity, and intracellular localization. The compounds were easily obtained in 34–80% yield. Based on the spectral properties and low cytotoxicity, we selected the quinolin-8-yl pentanoate derivative 17 for in vivo labeling of the ER. Fluorescence staining of the ER was evaluated by comparison with a commercial ER tracker. The molecules here developed are smaller than the alternatives commercially available while still presenting a high specificity towards the ER.

Oxidative C(sp3)-H functionalization of methyl-azaheteroarenes: a facile route to 1,2,4-triazolo[4,3-a]pyridines

We herein describe an oxidative [4 + 1] annulation used to prepare 1,2,4-triazolo[4,3-a]pyridines in the presence of I2-DMSO. This protocol enables synthesis of triazolo[4,3-a]pyridine-quinoline linked diheterocycles via a direct oxidative functionalization of sp3 C-H bonds of 2-methyl-azaheteroarenes. The reaction shows a wide substrate scope and good functional group tolerance.

Iodine-Catalyzed Construction of Dihydrooxepines via 3-Methyl-5-Pyrazolones C?H Oxidation/Functionalization of Quinolines Cascade

An efficient iodine-catalyzed [3+3+1] annulation for the construction of dihydrooxepine scaffolds with quinoline units was developed. This strategy involves a seven-membered dihydrooxepine with a broad substrate scope through a formal three-component tandem reaction. Further derivation of the target product produced a trioxabicycle scaffold, which formed the basic core of natural products and pharmaceutical molecules.

STIMULI - OR BIO- RESPONSIVE COPOLYMERS, THE POLYMERSOMES COMPRISING THE SAME AND THEIR USE IN DRUG DELIVERY

The present invention concerns amphiphilic copolymers that may be photo- or redox-cleavable and that may assemble into polymersomes. It also concerns their process of preparation and their use as drug carriers.

Selective Electrochemical Oxygenation of Alkylarenes to Carbonyls

An efficient electrochemical method for benzylic C(sp3)-H bond oxidation has been developed. A variety of methylarenes, methylheteroarenes, and benzylic (hetero)methylenes could be converted into the desired aryl aldehydes and aryl ketones in moderate to excellent yields in an undivided cell, using O2 as the oxygen source and lutidinium perchlorate as an electrolyte. On the basis of cyclic voltammetry studies, 18O labeling experiments, and radical trapping experiments, a possible single-electron transfer mechanism has been proposed for the electrooxidation reaction.