51221-38-6Relevant articles and documents
Solid-gas reactions for nitroxyl (HNO) generation in the gas phase
Carrone, Guillermo,Mazzeo, Agostina,Marceca, Ernesto,Pellegrino, Juan,Suárez, Sebastián,Zarenkiewicz, Jessica,Toscano, John P.,Doctorovich, Fabio
, (2021/07/25)
We present a novel nitroxyl (HNO) generation method, which avoids the need of using a liquid system or extreme experimental conditions. This method consists of the reaction between a gaseous base and an HNO donor (Piloty's acid) in the solid phase, allowi
Rapid generation of HNO induced by visible light
Carrone,Pellegrino,Doctorovich
supporting information, p. 5314 - 5317 (2017/07/07)
We present a new method for controlled generation of HNO, based on the combination of a pH photoactuator induced by visible light with an HNO donor activated by pH increase. This method avoids the use of UV light, and in the future could be extended by us
Piloty's acid derivative with improved nitroxyl-releasing characteristics
Aizawa, Kazuyuki,Nakagawa, Hidehiko,Matsuo, Kazuya,Kawai, Kodai,Ieda, Naoya,Suzuki, Takayoshi,Miyata, Naoki
supporting information, p. 2340 - 2343 (2013/05/09)
Recent studies have shown that nitroxyl (HNO) (1HNO/ 3NO-), which is the one-electron-reduced form of nitric oxide (NO), has unique biological activities, especially in the cardiovascular system, and HNO-releasing agents may have therapeutic potential. Since few HNO donors are available for use under physiological conditions, we synthesized and evaluated a series of Piloty's acid (PA) derivatives and evaluated their HNO-releasing activity under physiological conditions. N-Hydroxy-2- nitrobenzenesulfonamide (17) was the most efficient HNO donor among our synthesized PA derivatives, including the lead compound, 2-bromo-N- hydroxybenzenesulfonamide (2). The high HNO-releasing activity is suggested to be due to electronic and steric effects. Compound 17 may be a useful tool for biological experiments.
