51221-50-2

Basic information

• Product Name: DL-serine hydrochloride
• Synonyms: DL-serine hydrochloride
• CAS NO: 51221-50-2
• Molecular Weight: 141.554
• Mol File: 51221-50-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: DL-serine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: DL-serine hydrochloride(51221-50-2)
• EPA Substance Registry System: DL-serine hydrochloride(51221-50-2)

Safety Data

• Hazardous Substances Data: 51221-50-2(Hazardous Substances Data)

Upstream product

• 13734-38-8 N-(t-butyloxycarbonyl)-O-(t-butyl)-L-Serine 
• 1334715-72-8 versicoloritide C 
• 161771-71-7 methyl (3S)-3-(m-chlorobenzoyloxy)-N-trifluoroacetylalaninate 
• 56-45-1 L-serin 

Downstream Products

• 5619-04-5 methyl 2-amino-3-hydroxypropanoate hydrochloride 
• 3262-72-4 (S)-N-(tert-butoxycarbonyl)serine 
• 16354-58-8 N-acetyl-L-serine 
• 93527-55-0 (S)-2-(dibenzylamino)-3-hydroxypropanoic acid 
• 73724-45-5 N-(9H-fluoren-9-ylmethoxycarbonyl)-L-serine 
• 7625-65-2 L-carbobenzyloxy-β-chloroalanine 
• 126101-06-2 (3S)-3-hydroxymethyl-2,5-dioxohexahydro-1H-pyrrolo[1,2-a]-imidazole 
• 913650-17-6 methyl 2-((5-chloro-2-[(2-methylpropyl)oxy]phenyl)methyl)-4,5-dihydro-1,3-oxazole-4-carboxylate 
• 51887-89-9 β-chloro-L-alanine hydrochloride 
• 25840-83-9 O-trityl-serine 
• 5680-80-8 methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride 
• 127-17-3 2-oxo-propionic acid 
• 302-72-7 rac-Ala-OH 

Relevant articles and documents

Solvent-freeN-Boc deprotection byex situgeneration of hydrogen chloride gas

An efficient, scalable and sustainable method for the quantitative deprotection of thetert-butyl carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. We demonstrate theex situgeneration of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas. The solvent-free conditions allow deprotection of a wide variety ofN-Boc derivatives to obtain the hydrochloride salts in quantitative yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.

Cyclopeptides and polyketides from coral-associated fungus, Aspergillus versicolor LCJ-5-4

Three new cyclopentapeptides, versicoloritides A-C (1-3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1-4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 μM.

Stereospecific Synthesis of α-Deuteriated α-Amino Acids: Regiospecific Deuteriation of Chiral 3-Isopropyl-2,5-dimethoxy-3,6-dihydropyrazines

Base-catalysed deuteriation of (3R)- or (3S)-3-isopropyl-2,5-dimethoxy-3,6-dihydropyrazines in refluxing CH3O2H-2H2O gives the -isotopomer in excellent yields without disturbing the stereogenic centre at C-3.These compounds provide convenient and efficient access to a range of (R)- and (S)-α-deuteriated α-amino acids, including serine, aspartic acid, allylglycine and phenylalanine, via alkylation of the butyllithium generated C-6 anion.