51229-51-7

Basic information

• Product Name: 1-(4-(Bromomethyl)phenyl)ethanone
• Synonyms: 1-(4-(Bromomethyl)phenyl)ethanone;4'-BROMOMETHYLACETOPHENONE;Ethanone, 1-[4-(broMoMethyl)phenyl]-;1-[4-(broMoMethyl)phenyl]ethan-1-one;p-(Bromomethyl)acetophenone;p-Acetylbenzyl bromide;1-(4-(Bromomethyl)
• CAS NO: 51229-51-7
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.073
• Mol File: 51229-51-7.mol
• Article Data: 48

Chemical Properties

• Melting Point: 38.5-40.0℃
• Boiling Point: 134-136℃ (5 Torr)
• Flash Point: 94.1 °C
• Appearance: /
• Density: 1.416 g/cm³
• Vapor Pressure: 0.00195mmHg at 25°C
• Refractive Index: 1.563
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 1-(4-(Bromomethyl)phenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(Bromomethyl)phenyl)ethanone(51229-51-7)
• EPA Substance Registry System: 1-(4-(Bromomethyl)phenyl)ethanone(51229-51-7)

Safety Data

• Hazardous Substances Data: 51229-51-7(Hazardous Substances Data)

Usage

Description

1-(4-(Bromomethyl)phenyl)ethanone is an organic compound that features a bromomethyl group attached to a phenyl ring, which is connected to an ethanone group. This chemical structure endows it with specific reactivity and properties that make it valuable in various synthetic applications.

Uses

1. Used in Pharmaceutical Synthesis:
1-(4-(Bromomethyl)phenyl)ethanone is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly for the creation of dihydropyrimidine and thiopyrimidine derivatives. These derivatives have demonstrated antiviral properties, making them important in the development of new antiviral agents to combat viral infections.
2. Used in Chemical Research:
In the field of chemical research, 1-(4-(Bromomethyl)phenyl)ethanone serves as a versatile building block for the synthesis of a wide range of organic molecules. Its unique structure allows for further functionalization and modification, which can lead to the discovery of new compounds with potential applications in various industries.
3. Used in Material Science:
1-(4-(Bromomethyl)phenyl)ethanone may also find applications in material science, where its specific chemical properties could be exploited to develop new materials with tailored characteristics. For instance, its reactivity with other molecules could be utilized in the creation of novel polymers or coatings with specific properties.

InChI:InChI=1/C9H9BrO/c1-7(11)9-4-2-8(6-10)3-5-9/h2-5H,6H2,1H3

Upstream product

• 122-00-9 para-methylacetophenone 
• 75633-63-5 4-(hydroxymethyl)acetophenone 
• 78-67-1 2,2'-azobis(isobutyronitrile) 
• 622-96-8 4-methylethylbenzene 
• 108-88-3 toluene 

Downstream Products

• 51229-55-1 1-{4-[(phenylthio)methyl]phenyl}ethan-1-one 
• 1237521-90-2 2-(4-acetylbenzylthio)-6-benzyl-5-ethylpyrimidin-4(3H)-one 
• 1242054-47-2 C₃₃H₄₇NO₄ 
• 1242054-48-3 C₂₉H₃₉NO₂ 
• 14295-52-4 4-(diethyoxyphosphorylmethyl)benzoic acid methyl ester 
• 34541-73-6 trans-4,4'-dimethyl 4,4'-dicarboxylate-1,2-diphenylethylene 
• 100-31-2 Stilbene-4,4'-dicarboxylic acid 
• 1202852-60-5 4,4'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))dibenzoic acid 
• 100424-32-6 methyl 4-[(E)-2-(4-(E)-2-[4-methoxycarbonylphenyl]ethenylphenyl)ethenyl]benzoate 
• 95827-11-5 4’-(acetoxymethyl)acetophenone 
• 1002299-74-2 3-(4-azidomethylphenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol 

Relevant articles and documents

Dual-Metal N-Heterocyclic Carbene Complex (M = Au and Pd)-Functionalized UiO-67 MOF for Alkyne Hydration-Suzuki Coupling Tandem Reaction

Metal N-heterocyclic carbene complexes (NHC-M) have been recognized as an important class of organometallic catalysts. Herein, we demonstrate that different NHC-M (M = Au and Pd) species can be simultaneously introduced into a single metal organic framework (MOF) by direct assembly of NHC-M-decorated ligands and metal ions under solvothermal conditions. The obtained UiO-67-Au/Pd-NHBC MOF with different organometallic NHC-M species can be a highly reusable dual catalyst to sequentially promote alkyne hydration-Suzuki coupling reaction. The potential utility of this strategy is highlighted by the preparation of many more new multicatalysts of this type for various organic transformations in a sequential way.

Photocatalytic continuous bromination method

The invention provides a photocatalytic continuous bromination method. The method comprises the following steps: carrying out a first-stage photocatalytic continuous bromination reaction on a materialcontaining an aromatic substrate with a structural general formula I and a bromination reagent in a first continuous illumination reactor to form a first continuous system; overflowing the obtained first continuous system into a second continuous illumination reactor for a second-stage photocatalytic continuous bromination reaction to form a second continuous system; and purifying the second continuous system, wherein the structural general formula I is shown in the specification, R is selected from any one of carboxyl, ester group, NO2, CN, C1 to C8 alkyl and alkoxy, and R1 is C1 to C8 alkyl; n is 1 or 2; X is N or C, and the bromination reagent is Nbromo succinimide or dibromohydantoin. According to the bromination reagent, the selectivity of a product is improved, so the yield of the product is improved; the photocatalytic continuous bromination reaction of the two stages effectively relieves the reaction heat accumulation, and enhances the yield of the target product.

3-(4-phenyl-1H-2-imidazolyl)-1H-pyrazole compound as well as preparation method and application thereof

The invention relates to a 3-(4-phenyl-1H-2-imidazolyl)-1H-pyrazole compound as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry and pharmacotherapeutics. The invention provides application of a compound shown as a formula I or pharmaceutically acceptable salt thereof in preparation of drugs for treating tumor-related diseases, particularly an application in preparation of an Aurora A kinase specific inhibitor.