51229-59-5

Basic information

• Product Name: Benzonitrile, 4-[(phenylsulfonyl)methyl]-
• CAS NO: 51229-59-5
• Molecular Formula: C14H11NO2S
• Molecular Weight: 257.313
• Mol File: 51229-59-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[(phenylsulfonyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[(phenylsulfonyl)methyl]-(51229-59-5)
• EPA Substance Registry System: Benzonitrile, 4-[(phenylsulfonyl)methyl]-(51229-59-5)

Safety Data

• Hazardous Substances Data: 51229-59-5(Hazardous Substances Data)

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 874-86-2 4-cyanobenzyl chloride 
• 17201-43-3 4-cyanobenzyl bromide 
• 35525-86-1 4-cyano-N,N-dimethylbenzylamine 
• 41037-88-1 (α-Jod-4-cyan-benzyl)-phenyl-sulfon 
• 41037-77-8 4-(benzenesulfonyl-chloro-methyl)-benzonitrile 
• 41037-83-6 (α-Brom-4-cyan-benzyl)-phenyl-sulfon 

Downstream Products

• 41037-88-1 (α-Jod-4-cyan-benzyl)-phenyl-sulfon 
• 705966-24-1 1-cyano-4-[1-(phenylsulfonyl)ethenyl]benzene 
• 125951-06-6 (E)-4-[2-(phenylsulfonyl)vinyl]benzonitrile 
• 5462-71-5 4-cyanophenylacetic acid 
• 1449768-05-1 C₂₄H₂₇N₃O₅S 
• 1449787-36-3 C₁₄H₁₄N₂O₃S 
• 1243693-84-6 C₂₃H₁₄INO₂S 
• 1057717-23-3 4-[1-benzenesulfonyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(julolidin-9-yl)ethyl]benzonitrile 
• 1057717-25-5 4-[1-benzenesulfonyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(4-dimethylaminophenyl)ethyl]benzonitrile 
• 1057717-27-7 C₃₂H₂₅N₂O₄S^(1-)*K⁽¹⁺⁾ 

Relevant articles and documents

Cu2O-catalyzed C–S coupling of quaternary ammonium salts and sodium alkane-/arene-sulfinates

A new protocol for the synthesis of (enantioenriched) benzylic sulfones via the Cu2O-catalyzed C–S bond cross coupling of alkane-/arene-sulfinates and (enantioenriched) benzylic quaternary ammonium salts has been developed. The product benzylic sulfones were obtained in good to high yields (75–96%). Chiral arylmethyl sulfones with high enantiomeric excess (90–94% ee) were also synthesized in the presence of Cu2O and 1,1′-bis-(diphenylphosphino)ferrocene (dppf).

LONG CHAIN BASE SPHINGOSINE KINASE INHIBITORS

The invention relates to inhibitors of sphingosine kinase enzymatic activity, compounds and pharmaceutical compositions that inhibit sphingosine kinase 1 and sphingosine kinase 2 (SphK1 and SphK2) enzymes and further relates to methods of treating diseases and disorders mediated by sphingosine 1 phosphate activity, comprising administering an effective amount of sphingosine kinase inhibitors.

THIOREDOXIN AND THIOREDOXIN REDUCTASE INHIBITORS

The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones.