512776-93-1

Basic information

• Product Name: methyl 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoate
• Synonyms: methyl 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoate
• CAS NO: 512776-93-1
• Molecular Weight: 276.286
• Mol File: 512776-93-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoate(512776-93-1)
• EPA Substance Registry System: methyl 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanoate(512776-93-1)

Safety Data

• Hazardous Substances Data: 512776-93-1(Hazardous Substances Data)

Upstream product

• 58653-97-7 methyl 2-methyl-2-oxiranecarboxylate 
• 1765-93-1 4-fluoroboronic acid 
• 80-62-6 methacrylic acid methyl ester 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 371-42-6 4-Fluorothiophenol 

Relevant articles and documents

One-pot synthesis of β-hydroxysulfones and its application in the preparation of anticancer drug bicalutamide

An efficient one-pot multistep strategy has been developed, comprising auto-oxidative difunctionalization of alkenes, oxidation of sulfides, and a further reduction of peroxides for the synthesis of complex β-hydroxysulfone derivatives from phenthiols and alkenes. This method has several advantageous characteristics, including readily available substrates, low-cost and environmental benign reagents, nontoxic and renewable solvents, and mild reaction conditions. The application of this transformation to the multigram-scale preparation of the anticancer drug bicalutamide is accomplished.

Process for making bicalutamide and intermediates thereof

Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.